Interleukin-10 as a potential regulator of hepcidin homeostasis in overweight and obese children: A cross-sectional study in Taiwan

Jung Su Chang, Yu Ling Li, Chiou Han Lu, Eddy Owaga, Wei Yu Chen, Hung Yi Chiou

研究成果: 雜誌貢獻文章

15 引文 (Scopus)

摘要

Objective: A sharp increase in the prevalence of obesity and a decline in iron deficiency in children was observed between the two consecutive Nutrition and Health Surveys in Taiwan. The aim of this study was to evaluate the distribution of hepcidin in relation to nutritional status in children. Methods: 648 children ages 7 to 13 y living in Taipei and New Taipei City were enrolled in this study. Parameters for obesity, iron status, and inflammatory markers were evaluated. Results: There were no differences in the prevalence of iron deficiency and iron depletion between normal and overweight/obese children. A V-sharp hepcidin distribution curve was seen in normal weight children and overweight/obese boys. Serum hepcidin levels remained stable in overweight/obese girls during transition from childhood to teenager. Overweight/obese children had increased serum nitric oxide (NO) and interleukin (IL)-1β but decreased IL-10 concentration compared with normal weight children. A strong inverse relationship was found between IL-10 and body mass index (BMI; odds ratio (OR), 0.86, 95% confidence interval [CI], 0.83-0.89). By contrast, positive correlations were observed between BMI and IL-1β (OR, 1.60; 95% CI, 1.29-1.98); and between BMI and NO (OR, 1.04, 95% CI, 1.02-1.07). Multivariate linear regression analysis showed serum hepcidin was significantly correlated with IL-10 (β = 0.26, P <0.0001). Conclusions: Our results raise the possibility that IL-10 may play a role in iron homeostasis. Decreased circulating IL-10 concentration may temporary protect young overweight/obese girls against the development of iron deficiency. However, long-term decrease in hepcidin concentration may increase the risk for iron overload in overweight/obese children.

原文英語
頁(從 - 到)1165-1170
頁數6
期刊Nutrition
30
發行號10
DOIs
出版狀態已發佈 - 2014

指紋

Hepcidins
Taiwan
Interleukin-10
Homeostasis
Cross-Sectional Studies
Iron
Odds Ratio
Confidence Intervals
Interleukin-1
Nitric Oxide
Obesity
Serum
Weights and Measures
Iron Overload
Nutrition Surveys
Health Surveys
Nutritional Status
Linear Models
Body Mass Index
Regression Analysis

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Medicine(all)

引用此文

Interleukin-10 as a potential regulator of hepcidin homeostasis in overweight and obese children : A cross-sectional study in Taiwan. / Chang, Jung Su; Li, Yu Ling; Lu, Chiou Han; Owaga, Eddy; Chen, Wei Yu; Chiou, Hung Yi.

於: Nutrition, 卷 30, 編號 10, 2014, p. 1165-1170.

研究成果: 雜誌貢獻文章

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title = "Interleukin-10 as a potential regulator of hepcidin homeostasis in overweight and obese children: A cross-sectional study in Taiwan",
abstract = "Objective: A sharp increase in the prevalence of obesity and a decline in iron deficiency in children was observed between the two consecutive Nutrition and Health Surveys in Taiwan. The aim of this study was to evaluate the distribution of hepcidin in relation to nutritional status in children. Methods: 648 children ages 7 to 13 y living in Taipei and New Taipei City were enrolled in this study. Parameters for obesity, iron status, and inflammatory markers were evaluated. Results: There were no differences in the prevalence of iron deficiency and iron depletion between normal and overweight/obese children. A V-sharp hepcidin distribution curve was seen in normal weight children and overweight/obese boys. Serum hepcidin levels remained stable in overweight/obese girls during transition from childhood to teenager. Overweight/obese children had increased serum nitric oxide (NO) and interleukin (IL)-1β but decreased IL-10 concentration compared with normal weight children. A strong inverse relationship was found between IL-10 and body mass index (BMI; odds ratio (OR), 0.86, 95{\%} confidence interval [CI], 0.83-0.89). By contrast, positive correlations were observed between BMI and IL-1β (OR, 1.60; 95{\%} CI, 1.29-1.98); and between BMI and NO (OR, 1.04, 95{\%} CI, 1.02-1.07). Multivariate linear regression analysis showed serum hepcidin was significantly correlated with IL-10 (β = 0.26, P <0.0001). Conclusions: Our results raise the possibility that IL-10 may play a role in iron homeostasis. Decreased circulating IL-10 concentration may temporary protect young overweight/obese girls against the development of iron deficiency. However, long-term decrease in hepcidin concentration may increase the risk for iron overload in overweight/obese children.",
keywords = "Hepcidin, IL-10, Iron deficiency, Obese children, Taiwan",
author = "Chang, {Jung Su} and Li, {Yu Ling} and Lu, {Chiou Han} and Eddy Owaga and Chen, {Wei Yu} and Chiou, {Hung Yi}",
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doi = "10.1016/j.nut.2014.02.021",
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volume = "30",
pages = "1165--1170",
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TY - JOUR

T1 - Interleukin-10 as a potential regulator of hepcidin homeostasis in overweight and obese children

T2 - A cross-sectional study in Taiwan

AU - Chang, Jung Su

AU - Li, Yu Ling

AU - Lu, Chiou Han

AU - Owaga, Eddy

AU - Chen, Wei Yu

AU - Chiou, Hung Yi

PY - 2014

Y1 - 2014

N2 - Objective: A sharp increase in the prevalence of obesity and a decline in iron deficiency in children was observed between the two consecutive Nutrition and Health Surveys in Taiwan. The aim of this study was to evaluate the distribution of hepcidin in relation to nutritional status in children. Methods: 648 children ages 7 to 13 y living in Taipei and New Taipei City were enrolled in this study. Parameters for obesity, iron status, and inflammatory markers were evaluated. Results: There were no differences in the prevalence of iron deficiency and iron depletion between normal and overweight/obese children. A V-sharp hepcidin distribution curve was seen in normal weight children and overweight/obese boys. Serum hepcidin levels remained stable in overweight/obese girls during transition from childhood to teenager. Overweight/obese children had increased serum nitric oxide (NO) and interleukin (IL)-1β but decreased IL-10 concentration compared with normal weight children. A strong inverse relationship was found between IL-10 and body mass index (BMI; odds ratio (OR), 0.86, 95% confidence interval [CI], 0.83-0.89). By contrast, positive correlations were observed between BMI and IL-1β (OR, 1.60; 95% CI, 1.29-1.98); and between BMI and NO (OR, 1.04, 95% CI, 1.02-1.07). Multivariate linear regression analysis showed serum hepcidin was significantly correlated with IL-10 (β = 0.26, P <0.0001). Conclusions: Our results raise the possibility that IL-10 may play a role in iron homeostasis. Decreased circulating IL-10 concentration may temporary protect young overweight/obese girls against the development of iron deficiency. However, long-term decrease in hepcidin concentration may increase the risk for iron overload in overweight/obese children.

AB - Objective: A sharp increase in the prevalence of obesity and a decline in iron deficiency in children was observed between the two consecutive Nutrition and Health Surveys in Taiwan. The aim of this study was to evaluate the distribution of hepcidin in relation to nutritional status in children. Methods: 648 children ages 7 to 13 y living in Taipei and New Taipei City were enrolled in this study. Parameters for obesity, iron status, and inflammatory markers were evaluated. Results: There were no differences in the prevalence of iron deficiency and iron depletion between normal and overweight/obese children. A V-sharp hepcidin distribution curve was seen in normal weight children and overweight/obese boys. Serum hepcidin levels remained stable in overweight/obese girls during transition from childhood to teenager. Overweight/obese children had increased serum nitric oxide (NO) and interleukin (IL)-1β but decreased IL-10 concentration compared with normal weight children. A strong inverse relationship was found between IL-10 and body mass index (BMI; odds ratio (OR), 0.86, 95% confidence interval [CI], 0.83-0.89). By contrast, positive correlations were observed between BMI and IL-1β (OR, 1.60; 95% CI, 1.29-1.98); and between BMI and NO (OR, 1.04, 95% CI, 1.02-1.07). Multivariate linear regression analysis showed serum hepcidin was significantly correlated with IL-10 (β = 0.26, P <0.0001). Conclusions: Our results raise the possibility that IL-10 may play a role in iron homeostasis. Decreased circulating IL-10 concentration may temporary protect young overweight/obese girls against the development of iron deficiency. However, long-term decrease in hepcidin concentration may increase the risk for iron overload in overweight/obese children.

KW - Hepcidin

KW - IL-10

KW - Iron deficiency

KW - Obese children

KW - Taiwan

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