Interleukin-10 and Th2 cytokines differentially regulate osteopontin expression in human monocytes and dendritic cells

Satoshi Konno, John A. Eckman, Beverly Plunkett, Xinfang Li, Jeffery S. Berman, John Schroeder, Shau Ku Huang

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35 引文 斯高帕斯(Scopus)

摘要

Osteopontin (OPN) is a pleiotrophic phosphoprotein involved in homeostatic and pathophysiologic responses. It is known to be a chemotactic cytokine for dendritic cells (DCs), a critical cell type in both innate and adaptive immune responses. We report herein a contrasting role of interleukin-10 (IL-10) and Th2 cytokines in the regulation of OPN expression in human monocytes and monocyte-derived DCs (Mo-DCs). Our results showed first that the expression of OPN in monocytes and Mo-DCs was induced in a time-dependent and dose-dependent manner by IL-10 but was inhibited by IL-4 or IL-13. Further, the basal level of OPN expression was also inhibited by IL-4. This inhibitory effect of IL-4 was associated with a faster decay of OPN transcripts and a decreased proximal promoter activity of OPN in IL-4-treated cells. These results demonstrate a novel role of IL-10 and Th2 cytokines in the regulation of DC function through their contrasting regulatory activities on the expression of OPN.

原文英語
頁(從 - 到)562-567
頁數6
期刊Journal of Interferon and Cytokine Research
26
發行號8
DOIs
出版狀態已發佈 - 八月 1 2006
對外發佈

ASJC Scopus subject areas

  • 免疫學
  • 細胞生物學
  • 病毒學

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