Interleukin-1 receptor antagonist restores homeostatic function and limits multiorgan damage in heatstroke

Kun Hung Shen, Chen Kuei Chang, Mao Tsun Lin, Ching Ping Chang

研究成果: 雜誌貢獻文章

16 引文 (Scopus)

摘要

We attempt to investigate whether interleukin-1 receptor antagonist (IL-1ra) therapy improves survival during heatstroke by attenuating multiorgan dysfunction. Anesthetized rabbits, immediately after the onset of heatstroke, are divided into three major groups and given: nothing, normal saline (1 ml/kg, i.v.), or IL-1ra (200-400 μg per 1 ml/kg, i.v.). They are exposed to ambient temperature of 40°C to induce heatstroke. Another group of rabbits is exposed to room temperature (24°C) and used as normothermic controls. Hyperthermia, hypotension, cerebral ischemia and edema, hepatic and renal failure, increased levels of both nitric oxide metabolites (NOx -) and dihydroxybenzoic acid (DHBA) in plasma, hyperkalemia, respiratory alkalosis, and metabolic acidosis and hypoxia are all observed in vehicle-treated heatstroke animals. When the vehicle-treated animals undergo heat stress, their survival time values are found to be 12-18 min. Resuscitation with IL-1ra dose-dependently improves survival time (duration, 132-303 min). As compared with vehicle-treated heatstroke rabbits, IL-1ra therapy significantly causes attenuation of heatstroke-induced hyperthermia, hypotension, cerebral ischemia and edema, intracranial hypertension, hepatic and renal dysfunction, NOx- and DHBA overproduction, hyperkalemia, hypoxia, respiratory alkalosis, and metabolic acidosis. The results indicate that IL-1ra therapy may restore tissue blood flow and homeostatic function, and limit multiorgan dysfunction and death in heatstroke.
原文英語
頁(從 - 到)561-568
頁數8
期刊European Journal of Applied Physiology
103
發行號5
DOIs
出版狀態已發佈 - 七月 2008

指紋

Heat Stroke
Interleukin-1 Receptors
Respiratory Alkalosis
Respiratory Acidosis
Hyperkalemia
Brain Edema
Rabbits
Acidosis
Brain Ischemia
Controlled Hypotension
Induced Hyperthermia
Temperature
Acids
Intracranial Hypertension
Liver Failure
Resuscitation
Hypotension
Renal Insufficiency
Nitric Oxide
Fever

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

引用此文

Interleukin-1 receptor antagonist restores homeostatic function and limits multiorgan damage in heatstroke. / Shen, Kun Hung; Chang, Chen Kuei; Lin, Mao Tsun; Chang, Ching Ping.

於: European Journal of Applied Physiology, 卷 103, 編號 5, 07.2008, p. 561-568.

研究成果: 雜誌貢獻文章

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