Interleukin-1 receptor antagonist increases survival in rat heatstroke by reducing hypothalamic serotonin release

Wen Ta Chiu, Ting Yu Kao, Mao Tsun Lin

研究成果: 雜誌貢獻文章同行評審

27 引文 斯高帕斯(Scopus)

摘要

During onset of heatstroke, rats displayed higher values of hypothalamic serotonin release and score of hypothalamic neuronal damage, and lower values of mean arterial pressure and hypothalamic blood flow compared with normothermic control rats. In another group in which interleukin-1 receptor antagonist (IL-1 ra; 200 μg/kg, i.v.) was injected 30 or 60 min after the start of heat exposure, the augmented hypothalamic serotonin release, diminished hypothalamic blood flow, arterial hypotension and hypothalamic neuronal damage during heatstroke were reduced as compared to the saline control group. The survival time (interval between onset of heatstroke and death) of the heatstroke rats was prolonged by treatment with IL-1 ra. The data indicate that IL-1 ra increases survival during rat heatstroke by reducing hypothalamic serotonin release.

原文英語
頁(從 - 到)33-36
頁數4
期刊Neuroscience Letters
202
發行號1-2
DOIs
出版狀態已發佈 - 十二月 29 1995

ASJC Scopus subject areas

  • Neuroscience(all)

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