Interferon-β signaling contributes to ras transformation

Yu Chen Tsai, Sidney Pestka, Lu Hai Wang, Loren W. Runnels, Shan Wan, Yi Lisa Lyu, Leroy-Fong Liu

研究成果: 雜誌貢獻文章

21 引文 (Scopus)

摘要

Increasing evidence has pointed to activated type I interferon signaling in tumors. However, the molecular basis for such activation and its role in tumorigenesis remain unclear. In the current studies, we report that activation of type I interferon (IFN) signaling in tumor cells is primarily due to elevated secretion of the type I interferon, IFN-β. Studies in oncogene-transformed cells suggest that oncogenes such as Ras and Src can activate IFN-β signaling. Significantly, elevated IFN-β signaling in Ras-transformed mammary epithelial MCF-10A cells was shown to contribute to Ras transformation as evidenced by morphological changes, anchorage-independent growth, and migratory properties. Our results demonstrate for the first time that the type I IFN, IFN-β, contributes to Ras transformation and support the notion that oncogene-induced cytokines play important roles in oncogene transformation.

原文英語
文章編號e24291
期刊PLoS One
6
發行號8
DOIs
出版狀態已發佈 - 八月 29 2011
對外發佈Yes

指紋

Interferon Type I
interferons
Oncogenes
Interferons
oncogenes
Tumors
Chemical activation
Neoplasms
Carcinogenesis
Breast
Cells
Cytokines
Growth
carcinogenesis
breasts
cytokines
secretion
cells
neoplasms

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

引用此文

Tsai, Y. C., Pestka, S., Wang, L. H., Runnels, L. W., Wan, S., Lyu, Y. L., & Liu, L-F. (2011). Interferon-β signaling contributes to ras transformation. PLoS One, 6(8), [e24291]. https://doi.org/10.1371/journal.pone.0024291

Interferon-β signaling contributes to ras transformation. / Tsai, Yu Chen; Pestka, Sidney; Wang, Lu Hai; Runnels, Loren W.; Wan, Shan; Lyu, Yi Lisa; Liu, Leroy-Fong.

於: PLoS One, 卷 6, 編號 8, e24291, 29.08.2011.

研究成果: 雜誌貢獻文章

Tsai, YC, Pestka, S, Wang, LH, Runnels, LW, Wan, S, Lyu, YL & Liu, L-F 2011, 'Interferon-β signaling contributes to ras transformation', PLoS One, 卷 6, 編號 8, e24291. https://doi.org/10.1371/journal.pone.0024291
Tsai YC, Pestka S, Wang LH, Runnels LW, Wan S, Lyu YL 等. Interferon-β signaling contributes to ras transformation. PLoS One. 2011 8月 29;6(8). e24291. https://doi.org/10.1371/journal.pone.0024291
Tsai, Yu Chen ; Pestka, Sidney ; Wang, Lu Hai ; Runnels, Loren W. ; Wan, Shan ; Lyu, Yi Lisa ; Liu, Leroy-Fong. / Interferon-β signaling contributes to ras transformation. 於: PLoS One. 2011 ; 卷 6, 編號 8.
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