Interaction effects of ultrafine carbon black with iron and nickel on heart rate variability in spontaneously hypertensive rats

Chuen-Chau Chang, Jing Shiang Hwang, Chang Chuan Chan, Tsun J. Cheng

研究成果: 雜誌貢獻文章同行評審

28 引文 斯高帕斯(Scopus)

摘要

Background: Particulate matter (PM) has been reported to be associated with alterations in heart rate variability (HRV); however, the results are inconsistent. We propose that different components of PM cause the discrepancy. Objective: In this study, our goal was to determine whether different types exposure would cause different HRV effects, and to verify the interactions between co-exposing components. Methods: Ultrafine carbon black (ufCB; 14 nm; 415 μg and 830 μg), ferric sulfate [Fe2(SO4)3; 105 μg and 210 μg], nickel sulfate (NiSO4; 263 μg and 526 μg), and a combination of high-dose ufCB and low-dose Fe2(SO4)3 or NiSO4 were intratracheally instilled into spontaneously hypertensive rats. Radiotelemetry data were collected in rats for 72 hr at baseline and for 72 hr the following week to determine the response to exposure. Effects of exposure on 5-min average of normal-to-normal intervals (ANN), natural logarithm-transformed standard deviation of the normal-to-normal intervals (LnSDNN), and root mean square of successive differences of adjacent normal-to-normal intervals (LnRMSSD) were analyzed using self-control experimental designs. Results: Both high-and low-dose nfCB decreased ANN marginally around hour 30, with concurrent increases of LnSDNN. LnRMSSD returned to baseline levels after small initial increases. We observed minor effects after low-dose Fe and Ni instillation, whereas biphasic changes were noted after high-dose instillations. Combined exposures of ufCB and either Fe or Ni resulted in HRV trends different from values estimated from individual-component effects. Conclusions: Components in PM may induce different cardioregulatory responses, and a single component may induce different responses during different phases. Concurrent exposure to ufCB and Fe or Ni might introduce interactions on cardioregulatory effects. Also, the effect of PM may be mediated through complex interaction between different components of PM.

原文英語
頁(從 - 到)1012-1017
頁數6
期刊Environmental Health Perspectives
115
發行號7
DOIs
出版狀態已發佈 - 七月 2007

ASJC Scopus subject areas

  • 公共衛生、環境和職業健康
  • 健康、毒理學和誘變

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