Interaction between the left-handed Z-DNA and polyamine The crystal structure of the d(CG)3 and N-(2-aminoethyl)-1,4-diamino-butane complex

Hirofumi Ohishi, Shoko Kunisawa, Gijs van der Marel, Jacques H. van Boom, Alexander Rich, Andrew H.J. Wang, Ken ichi Tomita, Toshio Hakoshima

研究成果: 雜誌貢獻文章同行評審

28 引文 斯高帕斯(Scopus)

摘要

The DNA fragment d(CG)3 was co-crystallized with N-(2-aminoethyl)-1,4-diaminobutane (PA(24)), a chemically synthesized polyamine. The complex crystal contained one polyamine, 3 magnesium cations and one sodium cation per duplex of d(CG)3, and well diffracted the X-ray intensities up to 1.0 Å resolution. The d(CG)3 took a left-handed Z-DNA conformation, and the PA(24) molecule electrostatically interacted with the phosphate groups of the d(CG)3 duplex.

原文英語
頁(從 - 到)238-244
頁數7
期刊FEBS Letters
284
發行號2
DOIs
出版狀態已發佈 - 6月 24 1991
對外發佈

ASJC Scopus subject areas

  • 生物物理學
  • 結構生物學
  • 生物化學
  • 分子生物學
  • 遺傳學
  • 細胞生物學

指紋

深入研究「Interaction between the left-handed Z-DNA and polyamine The crystal structure of the d(CG)3 and N-(2-aminoethyl)-1,4-diamino-butane complex」主題。共同形成了獨特的指紋。

引用此