Interaction between HLA-B60 and HLA-B27 as a better predictor of ankylosing spondylitis in a taiwanese population

James Cheng-Chung Wei, Henry Wong Sung-Ching, Yu Wen Hsu, Ya Feng Wen, Wen Chang Wang, Ruey Hong Wong, Hsing Fang Lu, Floris A. Van Gaalen, Wei-Chiao Chang

研究成果: 雜誌貢獻文章

12 引文 斯高帕斯(Scopus)

摘要

Objective Ankylosing spondylitis (AS) is a form of chronic inflammatory spondyloarthritis (SpA) that causes pain and stiffness in spines or joints. Human leukocyte antigen B27 (HLA-B27) and B60 (HLA-B60) have been reported as major genetic risk factors of AS. In addition, rs13202464, located on major histocompatibility complex (MHC) region, showed high sensitivity (98.7%) and specificity (98.0%) for HLA-B27. Design The aim of our study is to test whether the interaction between HLA-B60 and HLA-B27 (rs13202464) can serve as a better predictor of AS. We have genotyped HLA-B60 and rs13202464 among 471 patients with AS and 557 healthy subjects. Combined risk factors were investigated to test the biological interaction. Results Our results indicated that the relative risk (RR) for HLA-B27+/HLA-B60- was 152 (95% CI 91 to 255) and it increased to 201 (95% CI 85 to 475) in HLA-B27+/HLA-B60+ patients (with HLA-B27-/HLA-B60- as reference). Combinational analysis of two risk factors (HLA-B27 +/HLA-B60+) showed a relative excess risk due to interaction (RERI) of 46.79 (95% CI:-117.58 to 211.16), attributable proportion (AP) of 0.23 (95% CI:-0.41 to 0.88) and a synergy index (S) of 1.31 (95% CI: 0.56 to 3.04). Conclusion In conclusion, genetic interaction analysis revealed that the interaction between HLA-B60 and HLA-B27 is a better marker for the risk of AS susceptibility in a Taiwanese population.
原文英語
文章編號A1223
期刊PLoS One
10
發行號10
DOIs
出版狀態已發佈 - 十月 15 2015

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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    Cheng-Chung Wei, J., Sung-Ching, H. W., Hsu, Y. W., Wen, Y. F., Wang, W. C., Wong, R. H., Lu, H. F., Van Gaalen, F. A., & Chang, W-C. (2015). Interaction between HLA-B60 and HLA-B27 as a better predictor of ankylosing spondylitis in a taiwanese population. PLoS One, 10(10), [A1223]. https://doi.org/10.1371/journal.pone.0137189