Insulin resistance without obesity induced by cotton pellet granuloma in mice

Hung Tsung Wu, Cheng Kuei Chang, Chiung Wen Tsao, Ya Ju Wen, Sheng Ming Ling, Kai Chun Cheng, Chi Jean Chang, Juei Tang Cheng

研究成果: 雜誌貢獻文章

17 引文 (Scopus)

摘要

Obesity leads to insulin resistance because the larger adipocytes in obese persons secrete proinflammatory cytokines that cause chronic inflammation in adipose tissue. This, in turn, leads to the alteration of adipokine secretion, which can induce insulin resistance. However, the development of insulin resistance without obesity is still obscure. We aimed to use an animal inflammation model with cotton pellet granuloma (CPG) in adipose tissue to characterize insulin resistance formation. We found that CPG in epididymal white adipose tissue (WAT), rather than in interscapular brown adipose tissue, impaired insulin sensitivity, and glucose utilization, and that it decreased levels of phosphoinsulin receptor and phospho-Akt in both muscle and liver tissue, but that it did not modify the body weight or food intake in mice. Macrophage infiltration in adipose tissue, leukocyte counts, monocyte chemoattractant protein-1, and interleukin-6 were elevated in CPG-treated mice. However, we found a marked decrease of plasma adiponectin only in the WAT group, which might have been because of the lower level of peroxisome proliferator-activated receptor-γ in WAT. These results show that granuloma formation in WAT by implantation of a cotton pellet may induce insulin resistance under nonobese condition through circulating inflammatory mediators, especially the low level of adiponectin.
原文英語
頁(從 - 到)362-369
頁數8
期刊Laboratory Investigation
89
發行號3
DOIs
出版狀態已發佈 - 三月 2009

指紋

Granuloma
Insulin Resistance
White Adipose Tissue
Obesity
Adipose Tissue
Adiponectin
Inflammation
Peroxisome Proliferator-Activated Receptors
Adipokines
Brown Adipose Tissue
Chemokine CCL2
Leukocyte Count
Adipocytes
Interleukin-6
Animal Models
Eating
Macrophages
Body Weight
Cytokines
Glucose

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology
  • Molecular Biology

引用此文

Insulin resistance without obesity induced by cotton pellet granuloma in mice. / Wu, Hung Tsung; Chang, Cheng Kuei; Tsao, Chiung Wen; Wen, Ya Ju; Ling, Sheng Ming; Cheng, Kai Chun; Chang, Chi Jean; Cheng, Juei Tang.

於: Laboratory Investigation, 卷 89, 編號 3, 03.2009, p. 362-369.

研究成果: 雜誌貢獻文章

Wu, HT, Chang, CK, Tsao, CW, Wen, YJ, Ling, SM, Cheng, KC, Chang, CJ & Cheng, JT 2009, 'Insulin resistance without obesity induced by cotton pellet granuloma in mice', Laboratory Investigation, 卷 89, 編號 3, 頁 362-369. https://doi.org/10.1038/labinvest.2008.161
Wu, Hung Tsung ; Chang, Cheng Kuei ; Tsao, Chiung Wen ; Wen, Ya Ju ; Ling, Sheng Ming ; Cheng, Kai Chun ; Chang, Chi Jean ; Cheng, Juei Tang. / Insulin resistance without obesity induced by cotton pellet granuloma in mice. 於: Laboratory Investigation. 2009 ; 卷 89, 編號 3. 頁 362-369.
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