摘要

Background. To investigate the association between insulin resistance (IR) and cardiovascular disease (CVD) risks among hemodialysis patients. Methods. We conducted a cross-sectional study between 2013 and 2017, on 384 hemodialysis patients from seven hospital-based-dialysis centers. HOMA-IR is classified according to median value. The CVD risks were defined by the K/DOQI Guidelines. Logistic regression analysis was used. Results. Patients' age was 60.9 ± 11.8, 58.1% men, and 40.3% overweight/obese. The median of HOMA-IR was 5.4, 82.8% high systolic blood pressure, and 85.7% hyperhomocysteinemia. In multivariate analysis, IR was significantly associated with higher odds of low high-density lipoprotein cholesterol, high triglyceride, and impaired fasting glucose in groups of normal weight, overweight/obese, nondiabetes, diabetes, and overall sample. IR linked with elevated high-sensitive C-reactive protein in normal weight patients (odd ratio, OR=2.21, 95% confidence interval, 1.16-4.22, p <.05), with hypoalbuminemia in normal weight patients (OR=8.31, 95% CI, 2.35-29.37, p <.01), in nondiabetes patients (OR=6.59, 95% CI, 1.81-23.95, p <.01), and overall sample (OR=3.07, 1.51-6.23, p <.01). Conclusions. The level of IR and prevalence of CVD risks were high in hemodialysis patients. IR was independently associated with CVD risks.
原文英語
文章編號1541593
期刊BioMed Research International
2019
DOIs
出版狀態已發佈 - 一月 1 2019

指紋

Multicenter Studies
Renal Dialysis
Insulin Resistance
Insulin
Cardiovascular Diseases
Weights and Measures
Hypoalbuminemia
Hyperhomocysteinemia
Dialysis
Blood pressure
Medical problems
Regression analysis
C-Reactive Protein
LDL Cholesterol
HDL Cholesterol
Logistics
Fasting
Triglycerides
Multivariate Analysis
Cross-Sectional Studies

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

引用此文

Insulin Resistance and Cardiovascular Risks in Different Groups of Hemodialysis Patients : A Multicenter Study. / Duong, Tuyen Van; Shih, Chun Kuang; Wong, Te Chih; Chen, Hsi Hsien; Chen, Tso Hsiao; Hsu, Yung Ho; Peng, Sheng Jeng; Kuo, Ko Lin; Liu, Hsiang Chung; Lin, En Tzu; Su, Chien Tien; Yang, Shwu Huey.

於: BioMed Research International, 卷 2019, 1541593, 01.01.2019.

研究成果: 雜誌貢獻文章

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abstract = "Background. To investigate the association between insulin resistance (IR) and cardiovascular disease (CVD) risks among hemodialysis patients. Methods. We conducted a cross-sectional study between 2013 and 2017, on 384 hemodialysis patients from seven hospital-based-dialysis centers. HOMA-IR is classified according to median value. The CVD risks were defined by the K/DOQI Guidelines. Logistic regression analysis was used. Results. Patients' age was 60.9 ± 11.8, 58.1{\%} men, and 40.3{\%} overweight/obese. The median of HOMA-IR was 5.4, 82.8{\%} high systolic blood pressure, and 85.7{\%} hyperhomocysteinemia. In multivariate analysis, IR was significantly associated with higher odds of low high-density lipoprotein cholesterol, high triglyceride, and impaired fasting glucose in groups of normal weight, overweight/obese, nondiabetes, diabetes, and overall sample. IR linked with elevated high-sensitive C-reactive protein in normal weight patients (odd ratio, OR=2.21, 95{\%} confidence interval, 1.16-4.22, p <.05), with hypoalbuminemia in normal weight patients (OR=8.31, 95{\%} CI, 2.35-29.37, p <.01), in nondiabetes patients (OR=6.59, 95{\%} CI, 1.81-23.95, p <.01), and overall sample (OR=3.07, 1.51-6.23, p <.01). Conclusions. The level of IR and prevalence of CVD risks were high in hemodialysis patients. IR was independently associated with CVD risks.",
author = "Duong, {Tuyen Van} and Shih, {Chun Kuang} and Wong, {Te Chih} and Chen, {Hsi Hsien} and Chen, {Tso Hsiao} and Hsu, {Yung Ho} and Peng, {Sheng Jeng} and Kuo, {Ko Lin} and Liu, {Hsiang Chung} and Lin, {En Tzu} and Su, {Chien Tien} and Yang, {Shwu Huey}",
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T1 - Insulin Resistance and Cardiovascular Risks in Different Groups of Hemodialysis Patients

T2 - A Multicenter Study

AU - Duong, Tuyen Van

AU - Shih, Chun Kuang

AU - Wong, Te Chih

AU - Chen, Hsi Hsien

AU - Chen, Tso Hsiao

AU - Hsu, Yung Ho

AU - Peng, Sheng Jeng

AU - Kuo, Ko Lin

AU - Liu, Hsiang Chung

AU - Lin, En Tzu

AU - Su, Chien Tien

AU - Yang, Shwu Huey

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background. To investigate the association between insulin resistance (IR) and cardiovascular disease (CVD) risks among hemodialysis patients. Methods. We conducted a cross-sectional study between 2013 and 2017, on 384 hemodialysis patients from seven hospital-based-dialysis centers. HOMA-IR is classified according to median value. The CVD risks were defined by the K/DOQI Guidelines. Logistic regression analysis was used. Results. Patients' age was 60.9 ± 11.8, 58.1% men, and 40.3% overweight/obese. The median of HOMA-IR was 5.4, 82.8% high systolic blood pressure, and 85.7% hyperhomocysteinemia. In multivariate analysis, IR was significantly associated with higher odds of low high-density lipoprotein cholesterol, high triglyceride, and impaired fasting glucose in groups of normal weight, overweight/obese, nondiabetes, diabetes, and overall sample. IR linked with elevated high-sensitive C-reactive protein in normal weight patients (odd ratio, OR=2.21, 95% confidence interval, 1.16-4.22, p <.05), with hypoalbuminemia in normal weight patients (OR=8.31, 95% CI, 2.35-29.37, p <.01), in nondiabetes patients (OR=6.59, 95% CI, 1.81-23.95, p <.01), and overall sample (OR=3.07, 1.51-6.23, p <.01). Conclusions. The level of IR and prevalence of CVD risks were high in hemodialysis patients. IR was independently associated with CVD risks.

AB - Background. To investigate the association between insulin resistance (IR) and cardiovascular disease (CVD) risks among hemodialysis patients. Methods. We conducted a cross-sectional study between 2013 and 2017, on 384 hemodialysis patients from seven hospital-based-dialysis centers. HOMA-IR is classified according to median value. The CVD risks were defined by the K/DOQI Guidelines. Logistic regression analysis was used. Results. Patients' age was 60.9 ± 11.8, 58.1% men, and 40.3% overweight/obese. The median of HOMA-IR was 5.4, 82.8% high systolic blood pressure, and 85.7% hyperhomocysteinemia. In multivariate analysis, IR was significantly associated with higher odds of low high-density lipoprotein cholesterol, high triglyceride, and impaired fasting glucose in groups of normal weight, overweight/obese, nondiabetes, diabetes, and overall sample. IR linked with elevated high-sensitive C-reactive protein in normal weight patients (odd ratio, OR=2.21, 95% confidence interval, 1.16-4.22, p <.05), with hypoalbuminemia in normal weight patients (OR=8.31, 95% CI, 2.35-29.37, p <.01), in nondiabetes patients (OR=6.59, 95% CI, 1.81-23.95, p <.01), and overall sample (OR=3.07, 1.51-6.23, p <.01). Conclusions. The level of IR and prevalence of CVD risks were high in hemodialysis patients. IR was independently associated with CVD risks.

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