Insulin-like growth factor (IGF) signaling requires αvβ3-IGF1- IGF type 1 receptor (IGF1R) ternary complex formation in anchorage independence, and the complex formation does not require IGF1R and Src activation

Masaaki Fujita, Yoko K. Takada, Yoshikazu Takada

研究成果: 雜誌貢獻文章

22 引文 斯高帕斯(Scopus)

摘要

Background: αvβ3 binds to IGF1, and the αvβ3-IGF1- IGF1R complex is formed in non-transformed cells. Results: IGF1 induces signals with the complex formation in anchorage independence. IGF1R or Src inhibitors did not suppress the complex formation. Conclusion: αvβ3-ECM interaction is not required for IGF signaling. The complex formation occurs before IGF1R activation. Significance: This study identifies new therapeutic targets in IGF signaling.

原文英語
頁(從 - 到)3059-3069
頁數11
期刊Journal of Biological Chemistry
288
發行號5
DOIs
出版狀態已發佈 - 二月 1 2013
對外發佈Yes

    指紋

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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