Insulin-like growth factor I stimulates transcription of the c-jun proto-oncogene in Balb c 3T3 cells

Shean Tai Chiou, Wen Chang Chang

研究成果: 雜誌貢獻文章同行評審

17 引文 斯高帕斯(Scopus)

摘要

Treatment of quiescent Balb c 3T3 cells with insulin-like growth factor I (IGF I) resulted in the stimulation of proto-oncogene c-jun transcription. Cells exposed to cycloheximide and IGF I together showed super-induction of c-jun transcripts. Nuclear run-off assay revealed that IGF I up-regulated c-jun only while cycloheximide was present. The stability of c-jun mRNA was markedly increased in the cells treated with IGF I. These results suggest that IGF I controls the expression of c-jun by increasing the transcriptional activity and stabilizing the existing transcripts.
原文英語
頁(從 - 到)524-531
頁數8
期刊Biochemical and Biophysical Research Communications
183
發行號2
DOIs
出版狀態已發佈 - 三月 16 1992
對外發佈Yes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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