Inside Cover: 1-Arylsulfonyl-5-(N-hydroxyacrylamide)indolines Histone Deacetylase Inhibitors Are Potent Cytokine Release Suppressors (ChemBioChem 10/2013)

Hsueh Yun Lee, Chia-Ron Yang, Mei-Jung Lai, Han-Li Huang, Yi-Ling Hsieh, Yi-Min Liu, Teng-Kuang Yeh, Yu-Hsuan Li, Samir Mehndiratta, Che-Ming Teng, Jing Ping Liou

研究成果: 雜誌貢獻文章

摘要

The inside cover picture shows a SAR study of synthetic N-hydroxyacrylamides, described by J.-P. Liou et al. on p. 1248 ff., that identified 3-[1- (4-methoxybenzenesulfonyl)-2,3-dihydro-1H-indol-5-yl]-N-hydroxyacrylamide as a potent HDAC inhibitor. This compound not only suppresses the production of lipopolysaccharide-induced cytokines but also markedly reduces carrageenan-induced inflammation in rat. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
原文英語
頁(從 - 到)1150
頁數1
期刊ChemBioChem
14
發行號10
DOIs
出版狀態已發佈 - 七月 2013

Keywords

  • Anti-inflammatory agents
  • Gene expression
  • Histone deacetylase
  • Indolines
  • Inhibitors

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology

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