Insertional activation of c-myc by reticuloendotheliosis virus in chicken B lymphoma: Nonrandom distribution and orientation of the proviruses

R. A. Swift, E. Shaller, R. L. Witter, H. J. Kung

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22 引文 斯高帕斯(Scopus)

摘要

Chicken syncytial virus, a member of the reticuloendotheliosis virus family, can induce chicken B lymphomas indistinguishable from those caused by avian leukosis virus. Previously, we have demonstrated that the chicken syncytial virus proviruses in these tumors are linked to the proto-oncogene c-myc. We have now determined the arrangement of chicken syncytial virus proviruses in 22 tumors. The results indicate that these proviruses, without exception, are integrated upstream from the second c-myc exon. At least 70% of these insertion sites are clustered in a 0.5-kilobase region immediately preceding the exon. The proviruses are all arranged in the same transcriptional orientation as c-myc. This type of provirus organization bears strong resemblance to that of the avian leukosis virus proviruses involved in c-myc activation.
原文英語
頁(從 - 到)869-872
頁數4
期刊Journal of Virology
54
發行號3
出版狀態已發佈 - 一月 1 1985
對外發佈

ASJC Scopus subject areas

  • 免疫學

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