Innovatively Therapeutic Strategy on Lung Cancer by Daily Drinking Antioxidative Plasmon-Induced Activated Water

Chien-Kai Wang, Hsiao-Chien Chen, Sheng-Uei Fang, Chia-Wen Ho, Cheng-Jeng Tai, Chih-Ping Yang, Yu-Chuan Liu

研究成果: 雜誌貢獻文章

2 引文 (Scopus)

摘要

Many human diseases are inflammation-related, such as cancer and those associated with aging. Previous studies demonstrated that plasmon-induced activated (PIA) water with electron-doping character, created from hot electron transfer via decay of excited Au nanoparticles (NPs) under resonant illumination, owns reduced hydrogen-bonded networks and physchemically antioxidative properties. In this study, it is demonstrated PIA water dramatically induced a major antioxidative Nrf2 gene in human gingival fibroblasts which further confirms its cellular antioxidative and anti-inflammatory properties. Furthermore, mice implanted with mouse Lewis lung carcinoma (LLC-1) cells drinking PIA water alone or together with cisplatin treatment showed improved survival time compared to mice which consumed only deionized (DI) water. With the combination of PIA water and cisplatin administration, the survival time of LLC-1-implanted mice markedly increased to 8.01 ± 0.77 days compared to 6.38 ± 0.61 days of mice given cisplatin and normal drinking DI water. This survival time of 8.01 ± 0.77 days compared to 4.62 ± 0.71 days of mice just given normal drinking water is statistically significant (p = 0.009). Also, the gross observations and eosin staining results suggested that LLC-1-implanted mice drinking PIA water tended to exhibit less metastasis than mice given only DI water.

原文英語
文章編號6316
頁(從 - 到)6316
期刊Scientific Reports
8
發行號1
DOIs
出版狀態已發佈 - 十二月 1 2018

指紋

Drinking
Lung Neoplasms
Water
Cisplatin
Therapeutics
Drinking Water
Survival
Electrons
Lewis Lung Carcinoma
Eosine Yellowish-(YS)
Lighting
Nanoparticles
Hydrogen
Anti-Inflammatory Agents
Fibroblasts
Staining and Labeling
Neoplasm Metastasis
Inflammation
Genes
Neoplasms

ASJC Scopus subject areas

  • General

引用此文

Innovatively Therapeutic Strategy on Lung Cancer by Daily Drinking Antioxidative Plasmon-Induced Activated Water. / Wang, Chien-Kai; Chen, Hsiao-Chien; Fang, Sheng-Uei; Ho, Chia-Wen; Tai, Cheng-Jeng; Yang, Chih-Ping; Liu, Yu-Chuan.

於: Scientific Reports, 卷 8, 編號 1, 6316, 01.12.2018, p. 6316.

研究成果: 雜誌貢獻文章

Wang, Chien-Kai ; Chen, Hsiao-Chien ; Fang, Sheng-Uei ; Ho, Chia-Wen ; Tai, Cheng-Jeng ; Yang, Chih-Ping ; Liu, Yu-Chuan. / Innovatively Therapeutic Strategy on Lung Cancer by Daily Drinking Antioxidative Plasmon-Induced Activated Water. 於: Scientific Reports. 2018 ; 卷 8, 編號 1. 頁 6316.
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