Innovative strategy with potential to increase hemodialysis efficiency and safety

Hsiao Chien Chen, Hsiu Chen Lin, Hsi Hsien Chen, Fu Der Mai, Yu Chuan Liu, Chun Mao Lin, Chun Chao Chang, Hui Yen Tsai, Chih Ping Yang

研究成果: 雜誌貢獻文章

20 引文 (Scopus)

摘要

Uremic toxins are mainly represented by blood urine nitrogen (BUN) and creatinine (Crea) whose removal is critically important in hemodialysis (HD) for kidney disease. Patients undergoing HD have a complex illness, resulting from: inadequate removal of organic waste, dialysis-induced oxidative stress and membrane-induced inflammation. Here we report innovative breakthroughs for efficient and safe HD by using a plasmon-induced dialysate comprising Au nanoparticles (NPs)-treated (AuNT) water that is distinguishable from conventional deionized (DI) water. The diffusion coefficient of K3 Fe(CN)6 in saline solution can be significantly increased from 2.76, to 4.62 × 10-6 cm s-1, by using AuNT water prepared under illumination by green light-emitting diodes (LED). In vitro HD experiments suggest that the treatment times for the removals of 70% BUN and Crea are reduced by 47 and 59%, respectively, using AuNT water instead of DI water in dialysate, while additionally suppressing NO release from lipopolysaccharide (LPS)-induced inflammatory cells.

原文英語
文章編號4425
期刊Scientific Reports
4
DOIs
出版狀態已發佈 - 三月 21 2014

指紋

Renal Dialysis
Safety
Water
Dialysis Solutions
Creatinine
Nitrogen
Urine
Methyl Green
Kidney Diseases
Lighting
Sodium Chloride
Nanoparticles
Lipopolysaccharides
Dialysis
Oxidative Stress
Inflammation
Membranes
Therapeutics

ASJC Scopus subject areas

  • General

引用此文

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abstract = "Uremic toxins are mainly represented by blood urine nitrogen (BUN) and creatinine (Crea) whose removal is critically important in hemodialysis (HD) for kidney disease. Patients undergoing HD have a complex illness, resulting from: inadequate removal of organic waste, dialysis-induced oxidative stress and membrane-induced inflammation. Here we report innovative breakthroughs for efficient and safe HD by using a plasmon-induced dialysate comprising Au nanoparticles (NPs)-treated (AuNT) water that is distinguishable from conventional deionized (DI) water. The diffusion coefficient of K3 Fe(CN)6 in saline solution can be significantly increased from 2.76, to 4.62 × 10-6 cm s-1, by using AuNT water prepared under illumination by green light-emitting diodes (LED). In vitro HD experiments suggest that the treatment times for the removals of 70{\%} BUN and Crea are reduced by 47 and 59{\%}, respectively, using AuNT water instead of DI water in dialysate, while additionally suppressing NO release from lipopolysaccharide (LPS)-induced inflammatory cells.",
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AU - Lin, Chun Mao

AU - Chang, Chun Chao

AU - Tsai, Hui Yen

AU - Yang, Chih Ping

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