Initial serum glucose level and white blood cell predict ventricular arrhythmia after first acute myocardial infarction

Jiann Hwa Chen, Chiu Liang Tseng, Shin Han Tsai, Wen Ta Chiu

研究成果: 雜誌貢獻文章

15 引文 (Scopus)

摘要

Objective: The aims of this study are to analyze the factors that predispose the occurrence of ventricular arrhythmia (VA) in young patients with a first acute myocardial infarction (AMI) in the emergency department (ED) and to establish predictive implications. Methods: This is a 10-year retrospective cohort study. Patients who were older than 18 years and younger than 45 years with a first attack of AMI were recruited from the ED of 3 university teaching hospitals from January 1, 1998, to December 31, 2007. Results: Five hundred young patients (472 men and 28 women) who met the inclusion criteria were enrolled. Within these patients, the incidence of life-threatening VA with first attack of AMI was 8% (n = 40). They were categorized into 2 groups: VA attack (n = 40) and non-VA attack (n = 460). In univariable analyses, acute anterolateral ST-segment elevation myocardial infarction (65% vs 47.8%; P = .04), elevate white blood cell (WBC) count (16.4 ± 3.4 vs 11.5 ± 3.1 × 103/mm3; P <.01), and initial serum glucose level (202.6 ± 90.9 vs 151.9 ± 64.7 mg/dL; P <.01) were significantly increased in the VA group. Multiple logistic regression model identified WBC count and initial serum glucose level as the significant independent variables in the prediction of VA attack for young patients with first attack of AMI. The receiver operating characteristic area for WBC count and serum glucose level in predicting the risk of VA occurring after AMI was 0.869 and 0.756, respectively. Conclusion: Initial serum glucose level and WBC may be used as valuable predictors for VA attack in young patients with first AMI.

原文英語
頁(從 - 到)418-423
頁數6
期刊American Journal of Emergency Medicine
28
發行號4
DOIs
出版狀態已發佈 - 五月 2010

指紋

Cardiac Arrhythmias
Leukocytes
Myocardial Infarction
Glucose
Serum
Leukocyte Count
Hospital Emergency Service
Logistic Models
Anterior Wall Myocardial Infarction
ROC Curve
Teaching Hospitals
Statistical Factor Analysis
Cohort Studies
Retrospective Studies
Incidence

ASJC Scopus subject areas

  • Emergency Medicine

引用此文

Initial serum glucose level and white blood cell predict ventricular arrhythmia after first acute myocardial infarction. / Chen, Jiann Hwa; Tseng, Chiu Liang; Tsai, Shin Han; Chiu, Wen Ta.

於: American Journal of Emergency Medicine, 卷 28, 編號 4, 05.2010, p. 418-423.

研究成果: 雜誌貢獻文章

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abstract = "Objective: The aims of this study are to analyze the factors that predispose the occurrence of ventricular arrhythmia (VA) in young patients with a first acute myocardial infarction (AMI) in the emergency department (ED) and to establish predictive implications. Methods: This is a 10-year retrospective cohort study. Patients who were older than 18 years and younger than 45 years with a first attack of AMI were recruited from the ED of 3 university teaching hospitals from January 1, 1998, to December 31, 2007. Results: Five hundred young patients (472 men and 28 women) who met the inclusion criteria were enrolled. Within these patients, the incidence of life-threatening VA with first attack of AMI was 8{\%} (n = 40). They were categorized into 2 groups: VA attack (n = 40) and non-VA attack (n = 460). In univariable analyses, acute anterolateral ST-segment elevation myocardial infarction (65{\%} vs 47.8{\%}; P = .04), elevate white blood cell (WBC) count (16.4 ± 3.4 vs 11.5 ± 3.1 × 103/mm3; P <.01), and initial serum glucose level (202.6 ± 90.9 vs 151.9 ± 64.7 mg/dL; P <.01) were significantly increased in the VA group. Multiple logistic regression model identified WBC count and initial serum glucose level as the significant independent variables in the prediction of VA attack for young patients with first attack of AMI. The receiver operating characteristic area for WBC count and serum glucose level in predicting the risk of VA occurring after AMI was 0.869 and 0.756, respectively. Conclusion: Initial serum glucose level and WBC may be used as valuable predictors for VA attack in young patients with first AMI.",
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N2 - Objective: The aims of this study are to analyze the factors that predispose the occurrence of ventricular arrhythmia (VA) in young patients with a first acute myocardial infarction (AMI) in the emergency department (ED) and to establish predictive implications. Methods: This is a 10-year retrospective cohort study. Patients who were older than 18 years and younger than 45 years with a first attack of AMI were recruited from the ED of 3 university teaching hospitals from January 1, 1998, to December 31, 2007. Results: Five hundred young patients (472 men and 28 women) who met the inclusion criteria were enrolled. Within these patients, the incidence of life-threatening VA with first attack of AMI was 8% (n = 40). They were categorized into 2 groups: VA attack (n = 40) and non-VA attack (n = 460). In univariable analyses, acute anterolateral ST-segment elevation myocardial infarction (65% vs 47.8%; P = .04), elevate white blood cell (WBC) count (16.4 ± 3.4 vs 11.5 ± 3.1 × 103/mm3; P <.01), and initial serum glucose level (202.6 ± 90.9 vs 151.9 ± 64.7 mg/dL; P <.01) were significantly increased in the VA group. Multiple logistic regression model identified WBC count and initial serum glucose level as the significant independent variables in the prediction of VA attack for young patients with first attack of AMI. The receiver operating characteristic area for WBC count and serum glucose level in predicting the risk of VA occurring after AMI was 0.869 and 0.756, respectively. Conclusion: Initial serum glucose level and WBC may be used as valuable predictors for VA attack in young patients with first AMI.

AB - Objective: The aims of this study are to analyze the factors that predispose the occurrence of ventricular arrhythmia (VA) in young patients with a first acute myocardial infarction (AMI) in the emergency department (ED) and to establish predictive implications. Methods: This is a 10-year retrospective cohort study. Patients who were older than 18 years and younger than 45 years with a first attack of AMI were recruited from the ED of 3 university teaching hospitals from January 1, 1998, to December 31, 2007. Results: Five hundred young patients (472 men and 28 women) who met the inclusion criteria were enrolled. Within these patients, the incidence of life-threatening VA with first attack of AMI was 8% (n = 40). They were categorized into 2 groups: VA attack (n = 40) and non-VA attack (n = 460). In univariable analyses, acute anterolateral ST-segment elevation myocardial infarction (65% vs 47.8%; P = .04), elevate white blood cell (WBC) count (16.4 ± 3.4 vs 11.5 ± 3.1 × 103/mm3; P <.01), and initial serum glucose level (202.6 ± 90.9 vs 151.9 ± 64.7 mg/dL; P <.01) were significantly increased in the VA group. Multiple logistic regression model identified WBC count and initial serum glucose level as the significant independent variables in the prediction of VA attack for young patients with first attack of AMI. The receiver operating characteristic area for WBC count and serum glucose level in predicting the risk of VA occurring after AMI was 0.869 and 0.756, respectively. Conclusion: Initial serum glucose level and WBC may be used as valuable predictors for VA attack in young patients with first AMI.

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