Inhibitory mechanisms of gabapentin, an antiseizure drug, on platelet aggregation

Chi Feng Pan, Ming Yi Shen, Chih Jen Wu, George Hsiao, Duen Suey Chou, Joen Rong Sheu

研究成果: 雜誌貢獻文章

13 引文 斯高帕斯(Scopus)

摘要

Gabapentin (Neurontin) is an analogue of gamma-aminobutyric acid (GABA) that is effective against partial seizures. Gabapentin has been reported to modulate serotonin release from platelets, but the effects of gabapentin on platelet activation have not been explored. In this study, gabapentin concentration-dependently (60-240 μM) inhibited platelet aggregation in washed platelets stimulated by collagen (1 μg mL-1), ADP (20 μM) and arachidonic acid (60 μM). Gabapentin (120 and 240 μM) also concentration-dependently inhibited collagen (1 μg mL-1)-induced phosphoinositide breakdown, intracellular Ca2+ mobilization, thromboxane A2 formation, and p38 MAPK phosphorylation in human platelets. In conclusion, the most important findings of this study suggest that gabapentin inhibits platelet aggregation, at least in part, through the phospholipase C-inositol 1,4,5-trisphosphate-thromboxane A2-Ca 2+ pathway. Thus, it is possible that gabapentin treatment, alone or in combination with other antiplatelet drugs, may induce or potentiate inhibition of platelet aggregation, which may affect haemostasis in-vivo.
原文英語
頁(從 - 到)1255-1261
頁數7
期刊Journal of Pharmacy and Pharmacology
59
發行號9
DOIs
出版狀態已發佈 - 九月 2007

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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