Inhibitory effects of terpenoids from the fermented broth of the ascomycete stilbohypoxylon elaeicola YMJ173 on nitric oxide production in RAW264.7 macrophages

Guei Jane Wang, Wen Li Liang, Yu Ming Ju, Wen Bin Yang, Ya Wen Chang, Zong-Huei Li

研究成果: 雜誌貢獻文章同行評審

8 引文 斯高帕斯(Scopus)

摘要

A series of six isopimarane-type diterpene glycosides, along with an eremophilane-type sesquiterpene, i.e., elaeicolasides A-C (1-3, resp.), 16-(α-D-mannopyranosyloxy)isopimar-7-en-19-oic acid (4), hymatoxin K (5), hymatoxin L (6), and elaeicolalactone (7), were isolated from the AcOEt extract of the fermented broth of Stilbohypoxylon elaeicola YMJ173. Among these, 1-3 and 7 are new compounds based on their spectroscopic data and sugar composition analysis. The effects of 1-7 on the inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-activated murine macrophage RAW264.7 cells were evaluated. All these compounds inhibited NO production, detected as nitrite in the culture medium, in activated macrophages without any cytotoxicity at a concentration of 100μM. Among these compounds, 2 showed a significant activity with the average maximum inhibition (E max) and median inhibitory concentration (IC 50) values of 93.3±0.5% and 79.3±0.4μM, respectively.

原文英語
頁(從 - 到)131-138
頁數8
期刊Chemistry and Biodiversity
9
發行號1
DOIs
出版狀態已發佈 - 一月 2012

ASJC Scopus subject areas

  • 生物化學
  • 化學 (全部)
  • 生物工程
  • 分子生物學
  • 分子醫學

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