Inhibitory effects of far-infrared irradiation generated by ceramic material on murine melanoma cell growth

Ting Kai Leung, Chin Feng Chan, Ping Shan Lai, Chih Hui Yang, Chia Yen Hsu, Yung Sheng Lin

研究成果: 雜誌貢獻文章

18 引文 斯高帕斯(Scopus)

摘要

The biological effects of specific wavelengths, so-called far-infrared radiation produced from ceramic material (cFIR), on whole organisms are not yet well understood. In this study, we investigated the biological effects of cFIR on murine melanoma cells (B16-F10) at body temperature. cFIR irradiation treatment for 48h resulted in an 11.8% decrease in the proliferation of melanoma cells relative to the control. Meanwhile, incubation of cells with cFIR for 48h significantly resulted in 56.9% and 15.7% decreases in the intracellular heat shock protein (HSP)70 and intracellular nitric oxide (iNO) contents, respectively. Furthermore, cFIR treatment induced 6.4% and 12.3% increases in intracellular reactive oxygen species stained by 5-(and 6)-carboxyl- 2 ′, 7 ′ -dichlorodihydrofluorescein diacetate and dihydrorhodamine 123, respectively. Since malignant melanomas are known to have high HSP70 expression and iNO activity, the suppressive effects of cFIR on HSP70 and NO may warrant future interest in antitumor applications.
原文英語
文章編號646845
期刊International Journal of Photoenergy
2012
DOIs
出版狀態已發佈 - 2012

ASJC Scopus subject areas

  • Renewable Energy, Sustainability and the Environment
  • Chemistry(all)
  • Atomic and Molecular Physics, and Optics
  • Materials Science(all)

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