Inhibitory effects of acylated kaempferol glycosides from the leaves of Cinnamomum kotoense on the proliferation of human peripheral blood mononuclear cells

Yuh Chi Kuo, Chung Kung Lu, Li Wei Huang, Yueh Hsiung Kuo, Chen Chang, Feng Lin Hsu, Zong-Huei Li

研究成果: 雜誌貢獻文章同行評審

19 引文 斯高帕斯(Scopus)

摘要

A new chemical entity, namely kaempferol 3-O-α-L-[2-(Z)-p-coumaroyl- 4-(E)-p-coumaroyl]rhamnopyranoside(1), and the known kaempferol 3-O-α-L-[2,4-di-(E)-p-coumaroyl]rhamnopyranoside (2) have been isolated from the methanolic extract of leaves of Cinnamomum kotoense. Structural elucidation of compounds 1 and 2 were achieved on the basis of spectroscopic analysis. The effects of compounds 1 and 2 on phytohemagglutinin (PHA) stimulated cell proliferation were studied towards human peripheral blood mononuclear cells (PBMC). The results indicated that compounds 1 and 2 suppressed PBMC proliferation induced by PHA with an IC50 value of 5.0 ± 1.3 and 6.0 ± 1.5 μM, respectively. Interleukin-2 production in activated PBMC inhibited by compounds 1 and 2 were in a concentration-dependent manner. Therefore, we suggested that compounds 1 and 2 in C. kotoense were likely the growth modulators for PBMC. copy; Georg Thieme Verlag KG Stuttgart.
原文英語
頁(從 - 到)412-415
頁數4
期刊Planta Medica
71
發行號5
DOIs
出版狀態已發佈 - 5月 2005

ASJC Scopus subject areas

  • 植物科學
  • 藥物發現
  • 有機化學
  • 藥理

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