Inhibitory effects of acylated kaempferol glycosides from the leaves of Cinnamomum kotoense on the proliferation of human peripheral blood mononuclear cells

Yuh Chi Kuo, Chung Kung Lu, Li Wei Huang, Yueh Hsiung Kuo, Chen Chang, Feng Lin Hsu, Zong-Huei Li

研究成果: 雜誌貢獻文章

18 引文 (Scopus)

摘要

A new chemical entity, namely kaempferol 3-O-α-L-[2-(Z)-p-coumaroyl- 4-(E)-p-coumaroyl]rhamnopyranoside(1), and the known kaempferol 3-O-α-L-[2,4-di-(E)-p-coumaroyl]rhamnopyranoside (2) have been isolated from the methanolic extract of leaves of Cinnamomum kotoense. Structural elucidation of compounds 1 and 2 were achieved on the basis of spectroscopic analysis. The effects of compounds 1 and 2 on phytohemagglutinin (PHA) stimulated cell proliferation were studied towards human peripheral blood mononuclear cells (PBMC). The results indicated that compounds 1 and 2 suppressed PBMC proliferation induced by PHA with an IC50 value of 5.0 ± 1.3 and 6.0 ± 1.5 μM, respectively. Interleukin-2 production in activated PBMC inhibited by compounds 1 and 2 were in a concentration-dependent manner. Therefore, we suggested that compounds 1 and 2 in C. kotoense were likely the growth modulators for PBMC. copy; Georg Thieme Verlag KG Stuttgart.
原文英語
頁(從 - 到)412-415
頁數4
期刊Planta Medica
71
發行號5
DOIs
出版狀態已發佈 - 五月 2005

指紋

Cinnamomum
kaempferol
mononuclear leukocytes
Glycosides
glycosides
Blood Cells
Blood
phytohemagglutinin
Cell proliferation
Phytohemagglutinins
leaves
cell proliferation
Cell Proliferation
Spectroscopic analysis
interleukin-2
leaf extracts
Modulators
Inhibitory Concentration 50
Interleukin-2
inhibitory concentration 50

ASJC Scopus subject areas

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

引用此文

Inhibitory effects of acylated kaempferol glycosides from the leaves of Cinnamomum kotoense on the proliferation of human peripheral blood mononuclear cells. / Kuo, Yuh Chi; Lu, Chung Kung; Huang, Li Wei; Kuo, Yueh Hsiung; Chang, Chen; Hsu, Feng Lin; Li, Zong-Huei.

於: Planta Medica, 卷 71, 編號 5, 05.2005, p. 412-415.

研究成果: 雜誌貢獻文章

Kuo, Yuh Chi ; Lu, Chung Kung ; Huang, Li Wei ; Kuo, Yueh Hsiung ; Chang, Chen ; Hsu, Feng Lin ; Li, Zong-Huei. / Inhibitory effects of acylated kaempferol glycosides from the leaves of Cinnamomum kotoense on the proliferation of human peripheral blood mononuclear cells. 於: Planta Medica. 2005 ; 卷 71, 編號 5. 頁 412-415.
@article{d6ccd5d0eff8425084108d77cbe23db9,
title = "Inhibitory effects of acylated kaempferol glycosides from the leaves of Cinnamomum kotoense on the proliferation of human peripheral blood mononuclear cells",
abstract = "A new chemical entity, namely kaempferol 3-O-α-L-[2-(Z)-p-coumaroyl- 4-(E)-p-coumaroyl]rhamnopyranoside(1), and the known kaempferol 3-O-α-L-[2,4-di-(E)-p-coumaroyl]rhamnopyranoside (2) have been isolated from the methanolic extract of leaves of Cinnamomum kotoense. Structural elucidation of compounds 1 and 2 were achieved on the basis of spectroscopic analysis. The effects of compounds 1 and 2 on phytohemagglutinin (PHA) stimulated cell proliferation were studied towards human peripheral blood mononuclear cells (PBMC). The results indicated that compounds 1 and 2 suppressed PBMC proliferation induced by PHA with an IC50 value of 5.0 ± 1.3 and 6.0 ± 1.5 μM, respectively. Interleukin-2 production in activated PBMC inhibited by compounds 1 and 2 were in a concentration-dependent manner. Therefore, we suggested that compounds 1 and 2 in C. kotoense were likely the growth modulators for PBMC. copy; Georg Thieme Verlag KG Stuttgart.",
keywords = "Acylated kaempferol glycosides, Cinnamomum kotoense, Interleukin-2, Lauraceae, Leaves, PBMC proliferation",
author = "Kuo, {Yuh Chi} and Lu, {Chung Kung} and Huang, {Li Wei} and Kuo, {Yueh Hsiung} and Chen Chang and Hsu, {Feng Lin} and Zong-Huei Li",
year = "2005",
month = "5",
doi = "10.1055/s-2005-864134",
language = "English",
volume = "71",
pages = "412--415",
journal = "Planta Medica",
issn = "0032-0943",
publisher = "Georg Thieme Verlag",
number = "5",

}

TY - JOUR

T1 - Inhibitory effects of acylated kaempferol glycosides from the leaves of Cinnamomum kotoense on the proliferation of human peripheral blood mononuclear cells

AU - Kuo, Yuh Chi

AU - Lu, Chung Kung

AU - Huang, Li Wei

AU - Kuo, Yueh Hsiung

AU - Chang, Chen

AU - Hsu, Feng Lin

AU - Li, Zong-Huei

PY - 2005/5

Y1 - 2005/5

N2 - A new chemical entity, namely kaempferol 3-O-α-L-[2-(Z)-p-coumaroyl- 4-(E)-p-coumaroyl]rhamnopyranoside(1), and the known kaempferol 3-O-α-L-[2,4-di-(E)-p-coumaroyl]rhamnopyranoside (2) have been isolated from the methanolic extract of leaves of Cinnamomum kotoense. Structural elucidation of compounds 1 and 2 were achieved on the basis of spectroscopic analysis. The effects of compounds 1 and 2 on phytohemagglutinin (PHA) stimulated cell proliferation were studied towards human peripheral blood mononuclear cells (PBMC). The results indicated that compounds 1 and 2 suppressed PBMC proliferation induced by PHA with an IC50 value of 5.0 ± 1.3 and 6.0 ± 1.5 μM, respectively. Interleukin-2 production in activated PBMC inhibited by compounds 1 and 2 were in a concentration-dependent manner. Therefore, we suggested that compounds 1 and 2 in C. kotoense were likely the growth modulators for PBMC. copy; Georg Thieme Verlag KG Stuttgart.

AB - A new chemical entity, namely kaempferol 3-O-α-L-[2-(Z)-p-coumaroyl- 4-(E)-p-coumaroyl]rhamnopyranoside(1), and the known kaempferol 3-O-α-L-[2,4-di-(E)-p-coumaroyl]rhamnopyranoside (2) have been isolated from the methanolic extract of leaves of Cinnamomum kotoense. Structural elucidation of compounds 1 and 2 were achieved on the basis of spectroscopic analysis. The effects of compounds 1 and 2 on phytohemagglutinin (PHA) stimulated cell proliferation were studied towards human peripheral blood mononuclear cells (PBMC). The results indicated that compounds 1 and 2 suppressed PBMC proliferation induced by PHA with an IC50 value of 5.0 ± 1.3 and 6.0 ± 1.5 μM, respectively. Interleukin-2 production in activated PBMC inhibited by compounds 1 and 2 were in a concentration-dependent manner. Therefore, we suggested that compounds 1 and 2 in C. kotoense were likely the growth modulators for PBMC. copy; Georg Thieme Verlag KG Stuttgart.

KW - Acylated kaempferol glycosides

KW - Cinnamomum kotoense

KW - Interleukin-2

KW - Lauraceae

KW - Leaves

KW - PBMC proliferation

UR - http://www.scopus.com/inward/record.url?scp=20544434772&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20544434772&partnerID=8YFLogxK

U2 - 10.1055/s-2005-864134

DO - 10.1055/s-2005-864134

M3 - Article

C2 - 15931577

AN - SCOPUS:20544434772

VL - 71

SP - 412

EP - 415

JO - Planta Medica

JF - Planta Medica

SN - 0032-0943

IS - 5

ER -