Inhibition of xanthine oxidase by purpurogallin and silymarin group

Shiow Yunn Sheu, Chih Hao Lai, Hsüch Ching Chiang

研究成果: 雜誌貢獻文章

30 引文 斯高帕斯(Scopus)

摘要

Thirteen phenolic compounds were tested for their inhibitory effects on xanthine oxidase. The enzyme xanthine oxidase catalyses the oxidation of hypoxanthine to xanthine and of xanthine to uric acid which has λmax of 295 nm, forming the basis for a spectrophotometric assay of the activity of xanthine oxidase. The results showed that purpurogallin and silymarin group displayed the inhibitory effects on xanthine oxidase (IC50 = 2.96 ± 0.12 and 27.58 ± 3.48 μM, respectively). Their apparent inhibition constants (Ki) were 1.16 and 5.85 μM, and induced uncompetitive and mixed type (non-competitive-uncompetitive) inhibitions respectively with respect to the substrate xanthine.

原文英語
頁(從 - 到)263-267
頁數5
期刊Anticancer Research
18
發行號1 A
出版狀態已發佈 - 一月 1998

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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  • 引用此

    Sheu, S. Y., Lai, C. H., & Chiang, H. C. (1998). Inhibition of xanthine oxidase by purpurogallin and silymarin group. Anticancer Research, 18(1 A), 263-267.