Inhibition of xanthine oxidase by cytokinins and related substances

Shiow Yunn Sheu, Y. U Chan Lin, Hsüch Ching Chiang

研究成果: 雜誌貢獻文章

9 引文 斯高帕斯(Scopus)

摘要

Fourteen cytokinins were tested for their inhibitory effects on xanthine oxidase. The enzyme, xanthine oxidase catalyses the oxidation of hypoxanthine to xanthine and of xanthine to uric acid which has λ(max) of 295 nm, forming the basis for a spectrophotometric assay of the activity of xanthine oxidase. The results showed that adenine-HCl, N 6-(2-isopentenyl)-adenine, purine and DL-dihydrozeatin displayed very potent activities (IC 50 = 1.92, 10.99, 60.98 and 86.36 μM respectively). Their apparent inhibition constants (Ki) were 2.20, 17.99, 13.59 and 115.62 μM, and induced competitive, uncompetitive, competitive and non-competitive type inhibitors respectively with respect to the substrate xanthine.

原文英語
頁(從 - 到)3571-3576
頁數6
期刊Anticancer Research
16
發行號6 B
出版狀態已發佈 - 1996

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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  • 引用此

    Sheu, S. Y., Lin, Y. U. C., & Chiang, H. C. (1996). Inhibition of xanthine oxidase by cytokinins and related substances. Anticancer Research, 16(6 B), 3571-3576.