Inhibition of the WNT/β-catenin pathway by fine particulate matter in haze: Roles of metals and polycyclic aromatic hydrocarbons

Kang Yun Lee, Jun Ji Cao, Chii Hong Lee, Ta Chih Hsiao, Chi-Tai Yeh, Thanh Tuan Huynh, Yong Ming Han, Xiang Dong Li, Kai Jen Chuang, Linwei Tian, Kin Fai Ho, Hsiao Chi Chuang

研究成果: 雜誌貢獻文章

5 引文 斯高帕斯(Scopus)

摘要

Air pollution might have a great impact on pulmonary health, but biological evidence in response to particulate matter less than 2.5μm in size (PM2.5) has been lacking. Physicochemical characterization of haze PM2.5 collected from Beijing, Xian and Hong Kong was performed. Biological pathways were identified by proteomic profiling in mouse lungs, suggesting that WNT/β-catenin is important in the response to haze PM2.5. Suppression of β-catenin levels, activation of caspase-3 and alveolar destruction, as well as IL-6, TNF-α and IFN-γ production, were observed in the lungs. The inhibition of β-catenin, TCF4 and cyclin D1 was observed invitro in response to haze PM2.5. The inhibition of WNT/β-catenin signaling, apoptosis-related results (caspase-3 and alveolar destruction), and inflammation, particularly including caspase-3 and alveolar destruction, were more highly associated with polycyclic aromatic hydrocarbons in haze PM2.5. In conclusion, decreased WNT/β-catenin expression modulated by haze PM2.5 could be involved in alveolar destruction and inflammation during haze episodes.
原文英語
頁(從 - 到)118-129
頁數12
期刊Atmospheric Environment
109
DOIs
出版狀態已發佈 - 五月 1 2015

    指紋

ASJC Scopus subject areas

  • Atmospheric Science
  • Environmental Science(all)

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