Inhibition of the WNT/β-catenin pathway by fine particulate matter in haze

Roles of metals and polycyclic aromatic hydrocarbons

Kang Yun Lee, Jun Ji Cao, Chii Hong Lee, Ta Chih Hsiao, Chi-Tai Yeh, Thanh Tuan Huynh, Yong Ming Han, Xiang Dong Li, Kai Jen Chuang, Linwei Tian, Kin Fai Ho, Hsiao Chi Chuang

研究成果: 雜誌貢獻文章

4 引文 (Scopus)

摘要

Air pollution might have a great impact on pulmonary health, but biological evidence in response to particulate matter less than 2.5μm in size (PM2.5) has been lacking. Physicochemical characterization of haze PM2.5 collected from Beijing, Xian and Hong Kong was performed. Biological pathways were identified by proteomic profiling in mouse lungs, suggesting that WNT/β-catenin is important in the response to haze PM2.5. Suppression of β-catenin levels, activation of caspase-3 and alveolar destruction, as well as IL-6, TNF-α and IFN-γ production, were observed in the lungs. The inhibition of β-catenin, TCF4 and cyclin D1 was observed invitro in response to haze PM2.5. The inhibition of WNT/β-catenin signaling, apoptosis-related results (caspase-3 and alveolar destruction), and inflammation, particularly including caspase-3 and alveolar destruction, were more highly associated with polycyclic aromatic hydrocarbons in haze PM2.5. In conclusion, decreased WNT/β-catenin expression modulated by haze PM2.5 could be involved in alveolar destruction and inflammation during haze episodes.
原文英語
頁(從 - 到)118-129
頁數12
期刊Atmospheric Environment
109
DOIs
出版狀態已發佈 - 五月 1 2015

指紋

haze
particulate matter
PAH
metal
proteomics
apoptosis
atmospheric pollution

ASJC Scopus subject areas

  • Atmospheric Science
  • Environmental Science(all)

引用此文

Inhibition of the WNT/β-catenin pathway by fine particulate matter in haze : Roles of metals and polycyclic aromatic hydrocarbons. / Lee, Kang Yun; Cao, Jun Ji; Lee, Chii Hong; Hsiao, Ta Chih; Yeh, Chi-Tai; Huynh, Thanh Tuan; Han, Yong Ming; Li, Xiang Dong; Chuang, Kai Jen; Tian, Linwei; Ho, Kin Fai; Chuang, Hsiao Chi.

於: Atmospheric Environment, 卷 109, 01.05.2015, p. 118-129.

研究成果: 雜誌貢獻文章

Lee, Kang Yun ; Cao, Jun Ji ; Lee, Chii Hong ; Hsiao, Ta Chih ; Yeh, Chi-Tai ; Huynh, Thanh Tuan ; Han, Yong Ming ; Li, Xiang Dong ; Chuang, Kai Jen ; Tian, Linwei ; Ho, Kin Fai ; Chuang, Hsiao Chi. / Inhibition of the WNT/β-catenin pathway by fine particulate matter in haze : Roles of metals and polycyclic aromatic hydrocarbons. 於: Atmospheric Environment. 2015 ; 卷 109. 頁 118-129.
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abstract = "Air pollution might have a great impact on pulmonary health, but biological evidence in response to particulate matter less than 2.5μm in size (PM2.5) has been lacking. Physicochemical characterization of haze PM2.5 collected from Beijing, Xian and Hong Kong was performed. Biological pathways were identified by proteomic profiling in mouse lungs, suggesting that WNT/β-catenin is important in the response to haze PM2.5. Suppression of β-catenin levels, activation of caspase-3 and alveolar destruction, as well as IL-6, TNF-α and IFN-γ production, were observed in the lungs. The inhibition of β-catenin, TCF4 and cyclin D1 was observed invitro in response to haze PM2.5. The inhibition of WNT/β-catenin signaling, apoptosis-related results (caspase-3 and alveolar destruction), and inflammation, particularly including caspase-3 and alveolar destruction, were more highly associated with polycyclic aromatic hydrocarbons in haze PM2.5. In conclusion, decreased WNT/β-catenin expression modulated by haze PM2.5 could be involved in alveolar destruction and inflammation during haze episodes.",
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