Inhibition of platelet aggregation by some flavonoids

Shu Huey Tzeng, Wun Chang Ko, Feng Nien Ko, Che Ming Teng

研究成果: 雜誌貢獻文章同行評審

186 引文 斯高帕斯(Scopus)

摘要

The inhibitory effects of five flavonoids on the aggregation and secretion of platelets were studied. These flavonoids inhibited markedly platelet aggregation and ATP release of rabbit platelets induced by arachidonic acid or collagen, and slightly those by platelet-activating factor. ADP-induced platelet aggregation was also suppressed by myricetin, fisetin and quercetin. The IC50 on arachidonic acid-induced platelet aggregation was: fisetin, 22 μM; kaempferol, 20 μM; quercetin, 13 μM; morin, 150 μM502 formations were also inhibited by flavonoids in platelets challenged with arachidonic acid. Fisetin, kaempferol, morin and quercetin antagonized the aggregation of washed platelets induced by U46619, a thromboxane A2/prostaglandin endoperoxides mimetic receptor agonist. In human platelet-rich plasma, quercetin prevented the secondary aggregation and blocked ATP release from platelets induced by epinephrine or ADP. These results demonstrate that the major antiplatelet effect of flavonoids tested may be due to both the inhibition of thromboxane formation and thromboxane receptor antagonism.
原文英語
頁(從 - 到)91-100
頁數10
期刊Thrombosis Research
64
發行號1
DOIs
出版狀態已發佈 - 十月 1 1991

ASJC Scopus subject areas

  • 心臟病學與心血管醫學
  • 血液學

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