Inhibition of Epstein-Barr virus lytic cycle by (-)-epigallocatechin gallate

Li Kwan Chang, Ta Tung Wei, Ya Fang Chiu, Chao Ping Tung, Jian Ying Chuang, Shang Kai Hung, Ching Li, Shih Tung Liu

研究成果: 雜誌貢獻文章同行評審

92 引文 斯高帕斯(Scopus)

摘要

(-)-Epigallocatechin gallate (EGCG), abundant in green tea, is a potent anti-microbial and anti-tumor compound. This investigation used immunoblot, flow cytometry, microarray, and indirect immunofluorescence analyses to show that at concentrations exceeding 50μM, EGCG inhibits the expression of Epstein-Barr virus (EBV) lytic proteins, including Rta, Zta, and EA-D, but does not affect the expression of EBNA-1. Moreover, DNA microarray and transient transfection analyses demonstrated that EGCG blocks EBV lytic cycle by inhibiting the transcription of immediate-early genes, thus inhibiting the initiation of EBV lytic cascade.
原文英語
頁(從 - 到)1062-1068
頁數7
期刊Biochemical and Biophysical Research Communications
301
發行號4
DOIs
出版狀態已發佈 - 二月 21 2003
對外發佈

ASJC Scopus subject areas

  • 生物物理學
  • 生物化學
  • 分子生物學
  • 細胞生物學

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