Inhibition of cardiac hypertrophy effects in d-galactose-induced senescent hearts by alpinate oxyphyllae fructus treatment

Yung Ming Chang, Hen Hong Chang, Hung Jen Lin, Chin Chuan Tsai, Chuan Te Tsai, Hsin Nung Chang, Shu Luan Lin, Vijaya Padmaviswanadha, Ray Jade Chen, Chih Yang Huang

研究成果: 雜誌貢獻文章

7 引文 斯高帕斯(Scopus)

摘要

Aging is a complex physiological phenomenon accelerated by ROS accumulation, with multisystem decline and increasing vulnerability to degenerative diseases and death. Cardiac hypertrophy is a key pathophysiological component that accompanies the aging process. Alpinate Oxyphyllae Fructus (Alpinia oxyphylla MIQ, AOF) is a traditional Chinese medicine, which provides cardioprotective activity against aging, hypertension, and cerebrovascular disorders. In this study, we found the protective effect of AOF against cardiac hypertrophy in D-galactose-induced aging rat model. The results showed that treating rats with D-galactose resulted in pathological hypertrophy as evident from the morphology change, increased left ventricular weight/whole heart weight, and expression of hypertrophy-related markers (MYH7 and BNP). Both concentric and eccentric cardiac hypertrophy signaling proteins were upregulated in aging rat model. However, these pathological changes were significantly improved in AOF treated group (AM and AH) in a dose-dependent manner. AOF negatively modulated D-galactose-induced cardiac hypertrophy signaling mechanism to attenuate ventricular hypertrophy. These enhanced cardioprotective activities following oral administration of AOF reflect the potential use of AOF for antiaging treatments.

原文英語
文章編號2624384
期刊Evidence-based Complementary and Alternative Medicine
2017
DOIs
出版狀態已發佈 - 2017

    指紋

ASJC Scopus subject areas

  • Complementary and alternative medicine

引用此

Chang, Y. M., Chang, H. H., Lin, H. J., Tsai, C. C., Tsai, C. T., Chang, H. N., Lin, S. L., Padmaviswanadha, V., Chen, R. J., & Huang, C. Y. (2017). Inhibition of cardiac hypertrophy effects in d-galactose-induced senescent hearts by alpinate oxyphyllae fructus treatment. Evidence-based Complementary and Alternative Medicine, 2017, [2624384]. https://doi.org/10.1155/2017/2624384