Inherited protein C deficiency with acute ischemic stroke in a young adult: A case report

Fu Chi Yang, Chang Hung Hsu, Jiann Chyun Lin, Cheng Yu Chen, Jiunn Tay Lee

研究成果: 雜誌貢獻文章同行評審

5 引文 斯高帕斯(Scopus)

摘要

Hereditary protein C deficiency is inherited primarily as an autosomal dominant trait with incomplete penetrance. Arterial thrombosis, especially of the intracranial arteries, due to this deficiency is relatively rare. A 31-year-old man was admitted to our department because of sudden onset of neurological symptoms. Magnetic resonance imaging of the brain disclosed an acute ischemic infarction of the area supplied by the left middle cerebral artery. Protein C antigen was 40.7% (77-129%) and protein C activity was 46.3% (70-140%). No other possible associated causes of stroke were present. A survey of his relatives for protein C deficiency showed this deficiency in his mother, brother, sister and nephews. Protein C concentrations should be determined in cases of ischemic stroke in all young patients with no other major risk factors. Once protein C deficiency is detected, a search for protein C deficiency in the patient?s relatives should be performed to prevent the occurrence of ischemic strokes.
原文英語
頁(從 - 到)601-604
頁數4
期刊Blood Coagulation and Fibrinolysis
19
發行號6
DOIs
出版狀態已發佈 - 九月 2008
對外發佈

ASJC Scopus subject areas

  • 血液學

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