Ingested arsenic, characteristics of well water consumption and risk of different histological types of lung cancer in northeastern Taiwan

Chi Ling Chen, Hung Y. Chiou, Ling I. Hsu, Yu Mei Hsueh, Meei Maan Wu, C. J. Chen Chien-Jen

研究成果: 雜誌貢獻文章

72 引文 (Scopus)

摘要

Our previous study combining two arseniasis-endemic areas in Taiwan confirmed a dose-response association of lung cancer and arsenic exposure. We conducted current analysis to elucidate the dose-response relationship in lower exposure level, and to evaluate whether the association differs in different histological types. In addition, whether specific characteristics of well water consumptions increased lung cancer risk was examined in order to establish a complete risk profile for arsenic exposure.A total of 8086 residents in northeastern Taiwan were followed for 11 years and 6888 participants remained in the final analysis because 1198 residents with unknown arsenic concentration were excluded. The 178 incident lung cancers were ascertained through linkage with the national cancer registry profiles in Taiwan. All analyses were performed by Cox's proportional hazards regression models.We found a significant dose-response trend (P=0.001) of lung cancer risk associated with increasing arsenic concentration. There was no apparent increased risk at concentrations between 10 and 100 μg/L, but concentrations between 100 and 300 μg/L showed evidence of excess risk (RR 1.54, 0.97-2.46). The relative risk was 2.25 (95% CI: 1.43, 3.55) for exposure to 300 μg/L when compared to

原文英語
頁(從 - 到)455-462
頁數8
期刊Environmental Research
110
發行號5
DOIs
出版狀態已發佈 - 七月 2010

指紋

Arsenic
well water
Taiwan
Drinking
arsenic
cancer
Lung Neoplasms
Water
dose-response relationship
hazard
Proportional Hazards Models
Registries
exposure
water consumption
Hazards
dose
analysis
cancer risk
Neoplasms

ASJC Scopus subject areas

  • Biochemistry
  • Environmental Science(all)

引用此文

Ingested arsenic, characteristics of well water consumption and risk of different histological types of lung cancer in northeastern Taiwan. / Chen, Chi Ling; Chiou, Hung Y.; Hsu, Ling I.; Hsueh, Yu Mei; Wu, Meei Maan; Chen Chien-Jen, C. J.

於: Environmental Research, 卷 110, 編號 5, 07.2010, p. 455-462.

研究成果: 雜誌貢獻文章

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