Influencing factors on cardiac structure and function beyond glycemic control in patients with type 2 diabetes mellitus

Ryoko Ichikawa, Masao Daimon, Tetsuro Miyazaki, Takayuki Kawata, Sakiko Miyazaki, Masaki Maruyama, Shuo Ju Chiang, Hiromasa Suzuki, Chiharu Ito, Fumihiko Sato, Hirotaka Watada, Hiroyuki Daida

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28 引文 斯高帕斯(Scopus)

摘要

Background: We hypothesized that clinical factors other than glycemic control may influence abnormal cardiac function in patients with type 2 diabetes mellitus (T2DM). We aimed to investigate the independent factors for abnormal cardiac function among clinical factors in T2DM.Methods: We studied 148 asymptomatic patients with T2DM without overt heart disease. Echocardiographic findings were compared between diabetic patients and 68 age-matched healthy subjects. Early (E) and late (A) diastolic mitral flow velocity and early diastolic mitral annular velocity (e') were measured for assessing left ventricular (LV) diastolic function. We evaluated insulin resistance, non-esterified fatty acid, high-sensitive CRP, estimated glomerular filtration rate, waist/hip ratio, abdominal visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT) and other clinical characteristics in addition to glycemic control. VAT and SAT were quantified by computed tomography.Results: In T2DM, E/A and e' were significantly lower, and E/e', left atrial volume and LV mass were significantly greater than in control subjects. In multivariate liner regression analysis, VAT was an independent determinant of left atrial volume (β =0.203, p=0.011), E/A (β =-0.208, p=0.002), e' (β =-0.354, p

原文英語
文章編號38
期刊Cardiovascular Diabetology
12
發行號1
DOIs
出版狀態已發佈 - 二月 27 2013
對外發佈Yes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Endocrinology, Diabetes and Metabolism

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