Influences of cardiac mechano-electrical feedback on action potential duration

J. C. Hsieh, Shih Ann Chen, Cheng Jeng Tai, John K J Li

研究成果: 書貢獻/報告類型會議貢獻

1 引文 斯高帕斯(Scopus)

摘要

A mathematical model of ventricular tissue, incorporated into stretch-activated channels (SACs) and volume-activated chloride currents (Icl,swell), was developed to investigate the interactions between cellular geometry and gap junctions in modulating action potential duration (APD). Results showed that (1) Shortening of APD was observed by activation of SACs using sustained axis-stretch in cellular uncoupling; however, lengthening of APD was observed in cellular coupling. (2) Shortening of APD was observed by activation of Icl,swell using radial swelling in both coupling and uncoupling. Thus, the alteration of APD by mechano-electrical feedback (MEF) in various gap junctions can be arrhythmogenic.
原文英語
主出版物標題Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
發行者IEEE
頁面142
頁數1
1
ISBN(列印)0780356756
出版狀態已發佈 - 1999
對外發佈Yes
事件Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) - Atlanta, GA, USA
持續時間: 十月 13 1999十月 16 1999

其他

其他Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
城市Atlanta, GA, USA
期間10/13/9910/16/99

    指紋

ASJC Scopus subject areas

  • Bioengineering

引用此

Hsieh, J. C., Chen, S. A., Tai, C. J., & Li, J. K. J. (1999). Influences of cardiac mechano-electrical feedback on action potential duration. 於 Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (卷 1, 頁 142). IEEE.