Influence of wet granulation and lubrication on the powder and tableting properties of codried product of microcrystalline cellulose with β-cyclodextrin

J. S. Wu, H. O. Ho, M. T. Sheu

研究成果: 雜誌貢獻文章

13 引文 斯高帕斯(Scopus)

摘要

The individual influence of wet granulation and lubrication on the powder and tableting properties of codried product of microcrystalline cellulose (MCC) with β-cyclodextrin (β-CD) was examined in this study. Avicel PH 101 and 301 were included for comparison. The codried product, Avicel PH 101 and 301 were granulated with water, and the granules were milled to retain three different size fractions: 37-60 μm, 60-150 μm, and 150-420 μm. The original Avicels and codried product were lubricated with magnesium stearate in three different percentages (0.2, 0.5, and 1.0%). The results showed that the powder flowability and disintegration of codried product and Avicels were significantly improved after wet granulation. However, the compactibility of codried product and Avicels decreased with increasing particle size. Nevertheless, the compactibility of the codried excipient after granulation was still better than the non-granulated Avicel PH 101 and 301. On the other hand, codried product and Avicels were sensitive to lubrication and resulted in decreasing compactibility and increasing disintegration. Because of the rounder shape of particles, the codried excipient was more sensitive to magnesium stearate and produced weaker tablets than did Avicels.
原文英語
頁(從 - 到)63-69
頁數7
期刊European Journal of Pharmaceutics and Biopharmaceutics
51
發行號1
DOIs
出版狀態已發佈 - 2001

ASJC Scopus subject areas

  • Biotechnology
  • Pharmaceutical Science

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