Influence of hyperbaric oxygen on tumor necrosis factor-α and nitric oxide production in endotoxin-induced acute lung injury in rats

Shi Jye Chu, Min Hui Li, Ching Wang Hsu, Shih Hung Tsai, Shih Hua Lin, Kun Lun Huang

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9 引文 斯高帕斯(Scopus)

摘要

We previously demonstrated that hyperbaric oxygen (HBO) treatment alleviated lipopolysaccharide (LPS)-induced acute lung injury in rats. However, the mechanisms responsible for the protective effect are still not fully understood. To obtain further information on the protective effect of HBO, in this study we investigated the role of tumor necrosis factor-α (TNF-α) and nitric oxide (NO) in intratracheal spraying LPS-induced acute lung injury in rats after HBO or hyperoxia treatment. The results showed that HBO but not hyperoxia attenuated the TNF-α level in plasma and bronchoalveolar lavage (BAL) fluid, NO concentration in BAL and plasma, and inducible NO synthase protein expression in lung tissue based on the Western blotting and immunohistochemical staining.

原文英語
頁(從 - 到)684-690
頁數7
期刊Pulmonary Pharmacology and Therapeutics
20
發行號6
DOIs
出版狀態已發佈 - 12月 2007
對外發佈

ASJC Scopus subject areas

  • 肺和呼吸系統醫學
  • 藥理

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