Influence of high serum alpha fetoprotein on patients with gastric cancer

Ming-Yao Chen, Wen-Liang Fang, Kuo-Hung Huang, Yu-Hsin Lai, Hwai-Jeng Lin

研究成果: 报告类型書籍

摘要

Backgrounds: Patients with alpha-fetoprotein (AFP)-producing gastric cancer (AFPGC) have a high incidence of liver metastasis and poor prognosis. However, the clinical manifestation of AFPGC remains controversial. Methods: We enrolled patients who, before surgery, had gastric cancer with serum AFP levels of >100 ng/mL (n = 30) and of ≦ 20 ng/mL (n = 1236). Clinical manifestations were compared between these two groups. Results: Compared with in the AFP > 100 group, early gastric cancer was more frequent (30.1% vs.0%) and advanced gastric cancer was less frequent (69.9% vs. 100%) in the AFP ≦ 20 ng/mL group (p < 0.001). Moreover, the incidence of liver and lymph node metastases was lower in the AFP ≦ 20 ng/mL group than in the AFP > 100 ng/mL group (4.4% vs. 43.3%, p < 0.001 and 60.7% vs. 93.3%,p < 0.001, respectively). More patients had stage IV AFPGC in the AFP > 100 ng/mL group than in the ≦ 20 ng/mL group (66.7% vs 27.1%, p < 0.001). Furthermore, fewer patients underwent curative surgery in the AFP > 100 ng/mL group (6.7% vs 37.9%, p < 0.001). More patients in the AFP > 100 ng/mL group died because of gastric cancer (66.7% vs 27.1%, p <0.0001).Conclusions: Patients with very high serum AFP levels have a high incidence of liver and lymph node metastases and extremely poor prognosis.
原文英語
頁數4
4
DOIs
出版狀態已發佈 - 六月 1 2017

Keywords

  • Gastric cancer
  • Alpha fetoprotein
  • Metastasis
  • Operation

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