Influence of glutathione-S-transferase theta (GSTT1) and mu (GSTM1) gene polymorphisms on the susceptibility of hepatocellular carcinoma in Taiwan

Chia Chun Kao, M. U Kuan Chen, W. U Hsien Kuo, Tzy Yen Chen, Shih Chi Su, Y. I Hsien Hsieh, Chuen Lan Liu, Ming Chih Chou, Hsiu Ting Tsai, Shun F A Yang

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6 引文 斯高帕斯(Scopus)

摘要

Background and Objectives: Hepatocellular carcinoma (HCC) is one of the most frequent malignant neoplasms worldwide and is the second leading cause of cancer death in Taiwan. Genetic polymorphism has been reported as a factor for increased susceptibility of HCC. Glutathione-S-transferases theta (GSTT1) and mu (GSTM1) play essential roles in detoxification of ingested xenobiotics and modulation of the susceptibility of gene-related cancer. The aim of this study was to estimate the relationships between these two gene polymorphisms and HCC risk and clinicopathological status in Taiwanese. Methods: Polymerase chain reaction (PCR) was used to determine gene polymorphisms of 102 patients with HCC and 386 healthy controls. Results: Both gene polymorphisms were not associated with the clinical pathological status of HCC and serum levels of liver-related clinical pathological markers. While no relationship between GSTM1 gene polymorphism and HCC susceptibility was found, individuals of age
原文英語
頁(從 - 到)301-307
頁數7
期刊Journal of Surgical Oncology
102
發行號4
DOIs
出版狀態已發佈 - 九月 15 2010
對外發佈Yes

ASJC Scopus subject areas

  • Surgery
  • Oncology

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