摘要

Background: To date, some experimental studies showed that inflammatory bowel disease (IBD) and bipolar disorder (BD) may share similar biological pathways. Nevertheless, only a few western studies have attempted to demonstrate the potential association between IBD and BD, and relevant findings are still conflicting. Therefore, this cross-sectional study aimed to evaluate the relationship between IBD and BD using a nationwide database in Taiwan. Method: This study used data from the National Health Insurance Research Database. In total, 3590 patients with IBD and 14,360 propensity score-matched comparison patients without IBD were included in this study. Conditional logistic regressions were performed to evaluate the association between BD and IBD. Results: Results showed that BD was found in 26 (0.72%) patients with IBD and in 49 (0.34%) matched comparison patients without IBD. After adjustment, the adjusted odds ratio (OR) of BD for IBD patients was 2.10 (95% confidence interval (CI): 1.30∼3.38) compared to the comparison group. Additionally, this study showed that adjusted OR of BD for ulcerative colitis patients were 2.23 (95% CI: 1.31∼3.82) compared to the comparison group. Limitations: we could not precisely determine the causal association between BD and IBD. Conclusions: We concluded that patients with IBD were more likely to have BD than those comparison patients without IBD.
原文英語
頁(從 - 到)120-124
頁數5
期刊Journal of Affective Disorders
247
DOIs
出版狀態已發佈 - 三月 15 2019

指紋

Bipolar Disorder
Inflammatory Bowel Diseases
Cross-Sectional Studies
Population
Odds Ratio
Databases
Confidence Intervals
Social Adjustment
Propensity Score
National Health Programs
Taiwan
Ulcerative Colitis
Logistic Models

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

引用此文

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title = "Inflammatory bowel disease and bipolar disorder: A population-based cross-sectional study",
abstract = "Background: To date, some experimental studies showed that inflammatory bowel disease (IBD) and bipolar disorder (BD) may share similar biological pathways. Nevertheless, only a few western studies have attempted to demonstrate the potential association between IBD and BD, and relevant findings are still conflicting. Therefore, this cross-sectional study aimed to evaluate the relationship between IBD and BD using a nationwide database in Taiwan. Method: This study used data from the National Health Insurance Research Database. In total, 3590 patients with IBD and 14,360 propensity score-matched comparison patients without IBD were included in this study. Conditional logistic regressions were performed to evaluate the association between BD and IBD. Results: Results showed that BD was found in 26 (0.72{\%}) patients with IBD and in 49 (0.34{\%}) matched comparison patients without IBD. After adjustment, the adjusted odds ratio (OR) of BD for IBD patients was 2.10 (95{\%} confidence interval (CI): 1.30∼3.38) compared to the comparison group. Additionally, this study showed that adjusted OR of BD for ulcerative colitis patients were 2.23 (95{\%} CI: 1.31∼3.82) compared to the comparison group. Limitations: we could not precisely determine the causal association between BD and IBD. Conclusions: We concluded that patients with IBD were more likely to have BD than those comparison patients without IBD.",
keywords = "Bipolar disorder, Crohn's disease, Inflammatory bowel disease, Ulcerative colitis",
author = "Kao, {Li Ting} and Lin, {Herng Ching} and Lee, {Hsin Chien}",
year = "2019",
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language = "English",
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journal = "Journal of Affective Disorders",
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T2 - A population-based cross-sectional study

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AU - Lin, Herng Ching

AU - Lee, Hsin Chien

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N2 - Background: To date, some experimental studies showed that inflammatory bowel disease (IBD) and bipolar disorder (BD) may share similar biological pathways. Nevertheless, only a few western studies have attempted to demonstrate the potential association between IBD and BD, and relevant findings are still conflicting. Therefore, this cross-sectional study aimed to evaluate the relationship between IBD and BD using a nationwide database in Taiwan. Method: This study used data from the National Health Insurance Research Database. In total, 3590 patients with IBD and 14,360 propensity score-matched comparison patients without IBD were included in this study. Conditional logistic regressions were performed to evaluate the association between BD and IBD. Results: Results showed that BD was found in 26 (0.72%) patients with IBD and in 49 (0.34%) matched comparison patients without IBD. After adjustment, the adjusted odds ratio (OR) of BD for IBD patients was 2.10 (95% confidence interval (CI): 1.30∼3.38) compared to the comparison group. Additionally, this study showed that adjusted OR of BD for ulcerative colitis patients were 2.23 (95% CI: 1.31∼3.82) compared to the comparison group. Limitations: we could not precisely determine the causal association between BD and IBD. Conclusions: We concluded that patients with IBD were more likely to have BD than those comparison patients without IBD.

AB - Background: To date, some experimental studies showed that inflammatory bowel disease (IBD) and bipolar disorder (BD) may share similar biological pathways. Nevertheless, only a few western studies have attempted to demonstrate the potential association between IBD and BD, and relevant findings are still conflicting. Therefore, this cross-sectional study aimed to evaluate the relationship between IBD and BD using a nationwide database in Taiwan. Method: This study used data from the National Health Insurance Research Database. In total, 3590 patients with IBD and 14,360 propensity score-matched comparison patients without IBD were included in this study. Conditional logistic regressions were performed to evaluate the association between BD and IBD. Results: Results showed that BD was found in 26 (0.72%) patients with IBD and in 49 (0.34%) matched comparison patients without IBD. After adjustment, the adjusted odds ratio (OR) of BD for IBD patients was 2.10 (95% confidence interval (CI): 1.30∼3.38) compared to the comparison group. Additionally, this study showed that adjusted OR of BD for ulcerative colitis patients were 2.23 (95% CI: 1.31∼3.82) compared to the comparison group. Limitations: we could not precisely determine the causal association between BD and IBD. Conclusions: We concluded that patients with IBD were more likely to have BD than those comparison patients without IBD.

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