Inflammation-induced hepcidin is associated with the development of anemia and coronary artery lesions in kawasaki disease

Ho Chang Kuo, Ya Ling Yang, Jiin Haur Chuang, Mao Meng Tiao, Hong Ren Yu, Li Tung Huang, Kuender D. Yang, Wei Chiao Chang, Chiu Ping Lee, Ying Hsien Huang

研究成果: 雜誌貢獻文章

24 引文 斯高帕斯(Scopus)

摘要

Purpose Kawasaki disease (KD) is a systemic febrile vasculitis complicated by coronary artery lesions (CAL). Anemia is common in patients with KD and is associated with a prolonged duration of active inflammation. Hepcidin is a central modulator of inflammation-associated anemia, acting via control of iron absorption and a direct inhibitory effect on erythropoiesis. The aims of this study were to investigate the role of inflammation-induced hepcidin in the development of anemia, the occurrence of CAL formation, and IVIG treatment response in patients with KD. Methods Eighty-six KD patients and 30 febrile controls were enrolled. Levels of interleukin (IL)-6 and serumhepcidin were measured in sera by enzyme-linked immunosorbent assay. Hemoglobin and serum iron levels were also measured. Results Hemoglobin and iron levels were lower in KD patients than in controls (p

原文英語
頁(從 - 到)746-752
頁數7
期刊Journal of Clinical Immunology
32
發行號4
DOIs
出版狀態已發佈 - 八月 2012
對外發佈Yes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

指紋 深入研究「Inflammation-induced hepcidin is associated with the development of anemia and coronary artery lesions in kawasaki disease」主題。共同形成了獨特的指紋。

  • 引用此

    Kuo, H. C., Yang, Y. L., Chuang, J. H., Tiao, M. M., Yu, H. R., Huang, L. T., Yang, K. D., Chang, W. C., Lee, C. P., & Huang, Y. H. (2012). Inflammation-induced hepcidin is associated with the development of anemia and coronary artery lesions in kawasaki disease. Journal of Clinical Immunology, 32(4), 746-752. https://doi.org/10.1007/s10875-012-9668-1