Inflammation-induced hepcidin is associated with the development of anemia and coronary artery lesions in kawasaki disease

Ho Chang Kuo, Ya Ling Yang, Jiin Haur Chuang, Mao Meng Tiao, Hong Ren Yu, Li Tung Huang, Kuender D. Yang, Wei Chiao Chang, Chiu Ping Lee, Ying Hsien Huang

研究成果: 雜誌貢獻文章

23 引文 (Scopus)

摘要

Purpose Kawasaki disease (KD) is a systemic febrile vasculitis complicated by coronary artery lesions (CAL). Anemia is common in patients with KD and is associated with a prolonged duration of active inflammation. Hepcidin is a central modulator of inflammation-associated anemia, acting via control of iron absorption and a direct inhibitory effect on erythropoiesis. The aims of this study were to investigate the role of inflammation-induced hepcidin in the development of anemia, the occurrence of CAL formation, and IVIG treatment response in patients with KD. Methods Eighty-six KD patients and 30 febrile controls were enrolled. Levels of interleukin (IL)-6 and serumhepcidin were measured in sera by enzyme-linked immunosorbent assay. Hemoglobin and serum iron levels were also measured. Results Hemoglobin and iron levels were lower in KD patients than in controls (p

原文英語
頁(從 - 到)746-752
頁數7
期刊Journal of Clinical Immunology
32
發行號4
DOIs
出版狀態已發佈 - 八月 2012
對外發佈Yes

指紋

Hepcidins
Mucocutaneous Lymph Node Syndrome
Anemia
Coronary Vessels
Inflammation
Iron
Hemoglobins
Fever
Systemic Vasculitis
Erythropoiesis
Intravenous Immunoglobulins
Serum
Interleukin-6
Enzyme-Linked Immunosorbent Assay

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

引用此文

Inflammation-induced hepcidin is associated with the development of anemia and coronary artery lesions in kawasaki disease. / Kuo, Ho Chang; Yang, Ya Ling; Chuang, Jiin Haur; Tiao, Mao Meng; Yu, Hong Ren; Huang, Li Tung; Yang, Kuender D.; Chang, Wei Chiao; Lee, Chiu Ping; Huang, Ying Hsien.

於: Journal of Clinical Immunology, 卷 32, 編號 4, 08.2012, p. 746-752.

研究成果: 雜誌貢獻文章

Kuo, Ho Chang ; Yang, Ya Ling ; Chuang, Jiin Haur ; Tiao, Mao Meng ; Yu, Hong Ren ; Huang, Li Tung ; Yang, Kuender D. ; Chang, Wei Chiao ; Lee, Chiu Ping ; Huang, Ying Hsien. / Inflammation-induced hepcidin is associated with the development of anemia and coronary artery lesions in kawasaki disease. 於: Journal of Clinical Immunology. 2012 ; 卷 32, 編號 4. 頁 746-752.
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abstract = "Purpose Kawasaki disease (KD) is a systemic febrile vasculitis complicated by coronary artery lesions (CAL). Anemia is common in patients with KD and is associated with a prolonged duration of active inflammation. Hepcidin is a central modulator of inflammation-associated anemia, acting via control of iron absorption and a direct inhibitory effect on erythropoiesis. The aims of this study were to investigate the role of inflammation-induced hepcidin in the development of anemia, the occurrence of CAL formation, and IVIG treatment response in patients with KD. Methods Eighty-six KD patients and 30 febrile controls were enrolled. Levels of interleukin (IL)-6 and serumhepcidin were measured in sera by enzyme-linked immunosorbent assay. Hemoglobin and serum iron levels were also measured. Results Hemoglobin and iron levels were lower in KD patients than in controls (p",
keywords = "Coronary artery lesion, Hemoglobin, Hepcidin, IL-6, Iron, Kawasaki disease",
author = "Kuo, {Ho Chang} and Yang, {Ya Ling} and Chuang, {Jiin Haur} and Tiao, {Mao Meng} and Yu, {Hong Ren} and Huang, {Li Tung} and Yang, {Kuender D.} and Chang, {Wei Chiao} and Lee, {Chiu Ping} and Huang, {Ying Hsien}",
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T1 - Inflammation-induced hepcidin is associated with the development of anemia and coronary artery lesions in kawasaki disease

AU - Kuo, Ho Chang

AU - Yang, Ya Ling

AU - Chuang, Jiin Haur

AU - Tiao, Mao Meng

AU - Yu, Hong Ren

AU - Huang, Li Tung

AU - Yang, Kuender D.

AU - Chang, Wei Chiao

AU - Lee, Chiu Ping

AU - Huang, Ying Hsien

PY - 2012/8

Y1 - 2012/8

N2 - Purpose Kawasaki disease (KD) is a systemic febrile vasculitis complicated by coronary artery lesions (CAL). Anemia is common in patients with KD and is associated with a prolonged duration of active inflammation. Hepcidin is a central modulator of inflammation-associated anemia, acting via control of iron absorption and a direct inhibitory effect on erythropoiesis. The aims of this study were to investigate the role of inflammation-induced hepcidin in the development of anemia, the occurrence of CAL formation, and IVIG treatment response in patients with KD. Methods Eighty-six KD patients and 30 febrile controls were enrolled. Levels of interleukin (IL)-6 and serumhepcidin were measured in sera by enzyme-linked immunosorbent assay. Hemoglobin and serum iron levels were also measured. Results Hemoglobin and iron levels were lower in KD patients than in controls (p

AB - Purpose Kawasaki disease (KD) is a systemic febrile vasculitis complicated by coronary artery lesions (CAL). Anemia is common in patients with KD and is associated with a prolonged duration of active inflammation. Hepcidin is a central modulator of inflammation-associated anemia, acting via control of iron absorption and a direct inhibitory effect on erythropoiesis. The aims of this study were to investigate the role of inflammation-induced hepcidin in the development of anemia, the occurrence of CAL formation, and IVIG treatment response in patients with KD. Methods Eighty-six KD patients and 30 febrile controls were enrolled. Levels of interleukin (IL)-6 and serumhepcidin were measured in sera by enzyme-linked immunosorbent assay. Hemoglobin and serum iron levels were also measured. Results Hemoglobin and iron levels were lower in KD patients than in controls (p

KW - Coronary artery lesion

KW - Hemoglobin

KW - Hepcidin

KW - IL-6

KW - Iron

KW - Kawasaki disease

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