Inflammation and the pathogenesis of atrial fibrillation

Yu Feng Hu, Yi Jen Chen, Yenn Jiang Lin, Shih Ann Chen

研究成果: 雜誌貢獻文章

263 引文 斯高帕斯(Scopus)

摘要

Atrial fibrillation (AF) is the most common cardiac arrhythmia. However, the development of preventative therapies for AF has been disappointing. The infiltration of immune cells and proteins that mediate the inflammatory response in cardiac tissue and circulatory processes is associated with AF. Furthermore, the presence of inflammation in the heart or systemic circulation can predict the onset of AF and recurrence in the general population, as well as in patients after cardiac surgery, cardioversion, and catheter ablation. Mediators of the inflammatory response can alter atrial electrophysiology and structural substrates, thereby leading to increased vulnerability to AF. Inflammation also modulates calcium homeostasis and connexins, which are associated with triggers of AF and heterogeneous atrial conduction. Myolysis, cardiomyocyte apoptosis, and the activation of fibrotic pathways via fibroblasts, transforming growth factor-β and matrix metalloproteases are also mediated by inflammatory pathways, which can all contribute to structural remodelling of the atria. The development of thromboembolism, a detrimental complication of AF, is also associated with inflammatory activity. Understanding the complex pathophysiological processes and dynamic changes of AF-associated inflammation might help to identify specific anti-inflammatory strategies for the prevention of AF.

原文英語
頁(從 - 到)230-243
頁數14
期刊Nature Reviews Cardiology
12
發行號4
DOIs
出版狀態已發佈 - 四月 23 2015

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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