Induction of fatty acid cyclooxygenase in rat aortic smooth muscle cells by estradiol

Wen Chang Chang, Junko Nakao, Sei itsu Murota, Hsin Hsiung Tai

研究成果: 雜誌貢獻文章

24 引文 斯高帕斯(Scopus)

摘要

We have previously reported that estradiol stimulates prostacyclin biosynthesis in cultured rat aortic smooth muscle cells by increasing fatty acid cyclooxygenase activity, and induction of new protein biosynthesis is involved since the effect of estradiol is blocked by cycloheximide treatment. In order to see whether estradiol stimulates de novo biosynthesis of fatty acid cyclooxygenase in cells, a specific radioimmunoassay of fatty acid cyclooxygenase was used to measure the enzyme. Estradiol significantly increased immunoreactive fatty acid cyclooxygenase in cells. Consequently, increase in cyclooxygenase activity results in the production of more prostaglandin endoperoxides for final increased synthesis of prostacyclin in these cells.

原文英語
頁(從 - 到)33-37
頁數5
期刊Prostaglandins, Leukotrienes and Medicine
10
發行號1
DOIs
出版狀態已發佈 - 1983
對外發佈Yes

    指紋

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology

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