Induction of differentiation in rat C6 glioma cells with saikosaponins

Yan J. Tsai, I. Ling Chen, Lin Y. Horng, Rong Tsun Wu

研究成果: 雜誌貢獻文章同行評審

36 引文 斯高帕斯(Scopus)

摘要

The effects of saikosaponins (a, b1, b2, c, d), isolated from Bupleurum Radix, on the induction of differentiation in rat C6 glioma cells were studied. Saikosaponins a and d were shown to inhibit cell proliferation and alter cell morphology. In addition to cytostasis, the enzymatic activities of glutamine synthetase (GS) and 2′,3′-cyclic nucleotide 3′-phosphohydrolase (CNP) were also noticeably increased after treatment with saikosaponin a. Nevertheless, saikosaponin d only showed an increase of GS activity, no significant changes in CNP activity were found. These results suggest that saikosaponin a can induce the differentiation of C6 glioma cells into astrocytes and/or oligodendrocytes, but saikosaponin d can only induce the differentiation of C6 glioma cells into astrocytes.
原文英語
頁(從 - 到)117-121
頁數5
期刊Phytotherapy Research
16
發行號2
DOIs
出版狀態已發佈 - 2002

ASJC Scopus subject areas

  • 有機化學
  • 藥物發現
  • 藥理

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