Indomethacin therapy in infants with advanced postnatal age and patent ductus arteriosus

B. Achanti, T. F. Yeh, R. S. Pildes

研究成果: 雜誌貢獻文章

24 引文 斯高帕斯(Scopus)

摘要

A trial of intravenous indomethacin therapy was performed on 11 premature infants whose postnatal age was 8 weeks or more (mean 65.3 days). In an attempt to maintain the desired plasma level, indomethacin was given at a dosage of 0.3 mg/kg, at 8-hour intervals (total dose 0.9 mg/kg) for a total of 3 doses. In spite of desirable plasma indomethacin levels (which ranged from 280-870 ng/ml) and area under the curve (24.1 μg/hr/ml), calculated from time to 0 to 24 hrs after the initial dose, none of the infants responded to indomethacin with ductus closure. There were a transient significant decrease in urine output, creatinine clearance, and fractional excretion of sodium. The present study confirms the clinical impression that Indomethacin is ineffective for the closure of ductus arteriosus in infants with advanced postnatal age.

原文英語
頁(從 - 到)250-253
頁數4
期刊Clinical and Investigative Medicine
9
發行號4
出版狀態已發佈 - 十二月 1 1986
對外發佈Yes

ASJC Scopus subject areas

  • Medicine(all)

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