37 引文 斯高帕斯(Scopus)

摘要

Non-steroidal anti-inflammatory drugs (NSAIDs) were shown to reduce the risk of colorectal cancer recurrence and are widely used to modulate inflammatory responses. Indomethacin is an NSAID. Herein, we reported that indomethacin can suppress cancer cell migration through its influence on the focal complexes formation. Furthermore, endothelial growth factor (EGF)-mediated Ca2+ influx was attenuated by indomethacin in a dose dependent manner. Our results identified a new mechanism of action for indomethacin: inhibition of calcium influx that is a key determinant of cancer cell migration.

原文英語
頁(從 - 到)6584-6596
頁數13
期刊Molecules
18
發行號6
DOIs
出版狀態已發佈 - 6月 2013

ASJC Scopus subject areas

  • 有機化學
  • 醫藥 (全部)

指紋

深入研究「Indomethacin inhibits cancer cell migration via attenuation of cellular calcium mobilization」主題。共同形成了獨特的指紋。

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