Indication-oriented ovulation induction in assisted reproduction

研究成果: 雜誌貢獻回顧型文獻

摘要

Background: Ovulation induction plays an important role in the pregnancy outcome of assisted reproduction. Individualized controlled ovarian hyper-stimulation (COH) based on the prediction of the ovarian response for each individual is regarded as the treatment of choice. Objective: This review summarizes the various protocols available at present and then examines the use of COH protocols for different causes of infertility. Results: The advantage and efficacy of mild stimulation are proposed as suitable for poor responders and women of advanced age. For women with endometriosis or adenomyosis, the reproductive outcomes of assisted reproduction benefit from prolonged downregulation with a gonadotropin-releasing hormone (GnRH) agonist before the start of ovarian stimulation. For high responders, a GnRH antagonist protocol facilitates a GnRH agonist trigger and the segmentation of in vitro fertilization cycle to avoid ovarian hyperstimulation syndrome. The efficacy of various adjuvant therapies, including growth hormone, estrogen, levothyroxine, vitamin D, melatonin and myo-inositol is also reviewed.
原文英語
頁(從 - 到)48-58
頁數11
期刊Current Women's Health Reviews
14
發行號1
DOIs
出版狀態已發佈 - 三月 1 2018

指紋

Ovulation Induction
Reproduction
Gonadotropin-Releasing Hormone
Adenomyosis
Ovarian Hyperstimulation Syndrome
Hormone Antagonists
Inositol
Melatonin
Endometriosis
Fertilization in Vitro
Pregnancy Outcome
Thyroxine
Vitamin D
Infertility
Growth Hormone
Estrogens
Down-Regulation
Therapeutics

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

引用此文

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abstract = "Background: Ovulation induction plays an important role in the pregnancy outcome of assisted reproduction. Individualized controlled ovarian hyper-stimulation (COH) based on the prediction of the ovarian response for each individual is regarded as the treatment of choice. Objective: This review summarizes the various protocols available at present and then examines the use of COH protocols for different causes of infertility. Results: The advantage and efficacy of mild stimulation are proposed as suitable for poor responders and women of advanced age. For women with endometriosis or adenomyosis, the reproductive outcomes of assisted reproduction benefit from prolonged downregulation with a gonadotropin-releasing hormone (GnRH) agonist before the start of ovarian stimulation. For high responders, a GnRH antagonist protocol facilitates a GnRH agonist trigger and the segmentation of in vitro fertilization cycle to avoid ovarian hyperstimulation syndrome. The efficacy of various adjuvant therapies, including growth hormone, estrogen, levothyroxine, vitamin D, melatonin and myo-inositol is also reviewed.",
keywords = "Adjuvant therapy, Assisted reproduction, Controlled ovarian hyper-stimulation, In vitro fertilization, Indication-oriented, Ovulation induction",
author = "Chen, {Chien Wen} and Lin, {Pei Hsuan} and Lee, {Yi Xuan} and Tan, {Shun Jen} and Chen, {Ching Hui} and Tzeng, {Chii Ruey}",
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AU - Chen, Chien Wen

AU - Lin, Pei Hsuan

AU - Lee, Yi Xuan

AU - Tan, Shun Jen

AU - Chen, Ching Hui

AU - Tzeng, Chii Ruey

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Background: Ovulation induction plays an important role in the pregnancy outcome of assisted reproduction. Individualized controlled ovarian hyper-stimulation (COH) based on the prediction of the ovarian response for each individual is regarded as the treatment of choice. Objective: This review summarizes the various protocols available at present and then examines the use of COH protocols for different causes of infertility. Results: The advantage and efficacy of mild stimulation are proposed as suitable for poor responders and women of advanced age. For women with endometriosis or adenomyosis, the reproductive outcomes of assisted reproduction benefit from prolonged downregulation with a gonadotropin-releasing hormone (GnRH) agonist before the start of ovarian stimulation. For high responders, a GnRH antagonist protocol facilitates a GnRH agonist trigger and the segmentation of in vitro fertilization cycle to avoid ovarian hyperstimulation syndrome. The efficacy of various adjuvant therapies, including growth hormone, estrogen, levothyroxine, vitamin D, melatonin and myo-inositol is also reviewed.

AB - Background: Ovulation induction plays an important role in the pregnancy outcome of assisted reproduction. Individualized controlled ovarian hyper-stimulation (COH) based on the prediction of the ovarian response for each individual is regarded as the treatment of choice. Objective: This review summarizes the various protocols available at present and then examines the use of COH protocols for different causes of infertility. Results: The advantage and efficacy of mild stimulation are proposed as suitable for poor responders and women of advanced age. For women with endometriosis or adenomyosis, the reproductive outcomes of assisted reproduction benefit from prolonged downregulation with a gonadotropin-releasing hormone (GnRH) agonist before the start of ovarian stimulation. For high responders, a GnRH antagonist protocol facilitates a GnRH agonist trigger and the segmentation of in vitro fertilization cycle to avoid ovarian hyperstimulation syndrome. The efficacy of various adjuvant therapies, including growth hormone, estrogen, levothyroxine, vitamin D, melatonin and myo-inositol is also reviewed.

KW - Adjuvant therapy

KW - Assisted reproduction

KW - Controlled ovarian hyper-stimulation

KW - In vitro fertilization

KW - Indication-oriented

KW - Ovulation induction

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