The rate of nonsusceptibility of penicillin-resistant Streptococcus pneumoniae strains to ceftriaxone increased significantly in Taiwan in 2005. Approximately 90% of the ceftriaxone-nonsusceptible isolates were found to be of four major serotypes (serotypes 6B, 14, 19F, and 23F). Seven amino acid alterations in the penicillin-binding protein 2B transpeptidase-encoding region specifically contributed to the resistance.
ASJC Scopus subject areas
- Pharmacology (medical)
- Infectious Diseases
Chiu, C. H., Su, L. H., Huang, Y. C., Lai, J. C., Chen, H. L., Wu, T. L., & Lin, T. Y. (2007). Increasing ceftriaxone resistance and multiple alterations of penicillin-binding proteins among penicillin-resistant Streptococcus pneumoniae isolates in Taiwan. Antimicrobial Agents and Chemotherapy, 51(9), 3404-3406. https://doi.org/10.1128/AAC.01563-06