摘要
Objective: The sensitivity of cytologic examination of pleural effusions is variable and not predictive of prognosis. Survivin is an inhibitor of apoptosis that may be a novel diagnostic/prognostic marker of cancers. This study aimed to determine the diagnostic and prognostic value of measuring survivin mRNA levels in pleural effusions. Methods: Eighty-eight consecutive pleural effusion samples were examined for both cytology and survivin mRNA level. The accuracy of diagnosis and the correlation between survivin mRNA level and survival in malignant pleural effusion (MPE) were determined. Pleural effusions were divided into three groups: Group I, malignancy-associated (n = 44); Group II, inflammatory (n = 27); and Group III, transudative (n = 17). Results: Survivin mRNA levels in Group I (1.03±0.61, range 0-2.96) were significantly higher than those in Groups II (0.45±0.69, range 0-3.30) and III (0.08±0.22, range 00.71) (P, 0.001). Survivin mRNA level was significantly higher in MPE than in non-MPE. The cut-off value for survivin mRNA levels in pleural effusions was 0.074 for the diagnosis of malignancies, with sensitivity, specificity, and positive and negative predictive values of 96%, 45%, 45% and 96%, respectively. Survivin mRNA level in pleural effusions of cancer patients significantly correlated with poor survival. Conclusions: Survivin mRNA level is significantly higher in MPEs. Over-expression of survivin mRNA correlates with poor prognosis in cancer patients.
| 原文 | 英語 |
|---|---|
| 文章編號 | hyp151 |
| 頁（從 - 到） | 234-240 |
| 頁數 | 7 |
| 期刊 | Japanese Journal of Clinical Oncology |
| 卷 | 40 |
| 發行號 | 3 |
| DOIs | |
| 出版狀態 | 已發佈 - 十一月 22 2009 |
| 對外發佈 | Yes |
指紋
ASJC Scopus subject areas
- Oncology
- Cancer Research
- Radiology Nuclear Medicine and imaging
引用此文
Increased survivin mRNA in malignant pleural effusion is significantly correlated with survival. / Lan, Chou Chin; Wu, Yao Kuang; Lee, Chih Hsin; Huang, Yi Chih; Huang, Chun Yao; Tsai, Ying Huang; Huang, Shiu Feng; Tsao, Thomas Chang Yao.
於: Japanese Journal of Clinical Oncology, 卷 40, 編號 3, hyp151, 22.11.2009, p. 234-240.研究成果: 雜誌貢獻 › 文章
}
TY - JOUR
T1 - Increased survivin mRNA in malignant pleural effusion is significantly correlated with survival
AU - Lan, Chou Chin
AU - Wu, Yao Kuang
AU - Lee, Chih Hsin
AU - Huang, Yi Chih
AU - Huang, Chun Yao
AU - Tsai, Ying Huang
AU - Huang, Shiu Feng
AU - Tsao, Thomas Chang Yao
PY - 2009/11/22
Y1 - 2009/11/22
N2 - Objective: The sensitivity of cytologic examination of pleural effusions is variable and not predictive of prognosis. Survivin is an inhibitor of apoptosis that may be a novel diagnostic/prognostic marker of cancers. This study aimed to determine the diagnostic and prognostic value of measuring survivin mRNA levels in pleural effusions. Methods: Eighty-eight consecutive pleural effusion samples were examined for both cytology and survivin mRNA level. The accuracy of diagnosis and the correlation between survivin mRNA level and survival in malignant pleural effusion (MPE) were determined. Pleural effusions were divided into three groups: Group I, malignancy-associated (n = 44); Group II, inflammatory (n = 27); and Group III, transudative (n = 17). Results: Survivin mRNA levels in Group I (1.03±0.61, range 0-2.96) were significantly higher than those in Groups II (0.45±0.69, range 0-3.30) and III (0.08±0.22, range 00.71) (P, 0.001). Survivin mRNA level was significantly higher in MPE than in non-MPE. The cut-off value for survivin mRNA levels in pleural effusions was 0.074 for the diagnosis of malignancies, with sensitivity, specificity, and positive and negative predictive values of 96%, 45%, 45% and 96%, respectively. Survivin mRNA level in pleural effusions of cancer patients significantly correlated with poor survival. Conclusions: Survivin mRNA level is significantly higher in MPEs. Over-expression of survivin mRNA correlates with poor prognosis in cancer patients.
AB - Objective: The sensitivity of cytologic examination of pleural effusions is variable and not predictive of prognosis. Survivin is an inhibitor of apoptosis that may be a novel diagnostic/prognostic marker of cancers. This study aimed to determine the diagnostic and prognostic value of measuring survivin mRNA levels in pleural effusions. Methods: Eighty-eight consecutive pleural effusion samples were examined for both cytology and survivin mRNA level. The accuracy of diagnosis and the correlation between survivin mRNA level and survival in malignant pleural effusion (MPE) were determined. Pleural effusions were divided into three groups: Group I, malignancy-associated (n = 44); Group II, inflammatory (n = 27); and Group III, transudative (n = 17). Results: Survivin mRNA levels in Group I (1.03±0.61, range 0-2.96) were significantly higher than those in Groups II (0.45±0.69, range 0-3.30) and III (0.08±0.22, range 00.71) (P, 0.001). Survivin mRNA level was significantly higher in MPE than in non-MPE. The cut-off value for survivin mRNA levels in pleural effusions was 0.074 for the diagnosis of malignancies, with sensitivity, specificity, and positive and negative predictive values of 96%, 45%, 45% and 96%, respectively. Survivin mRNA level in pleural effusions of cancer patients significantly correlated with poor survival. Conclusions: Survivin mRNA level is significantly higher in MPEs. Over-expression of survivin mRNA correlates with poor prognosis in cancer patients.
KW - Cancer
KW - Pleural effusion
KW - Prognosis
KW - Survivin
UR - http://www.scopus.com/inward/record.url?scp=77950344002&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77950344002&partnerID=8YFLogxK
U2 - 10.1093/jjco/hyp151
DO - 10.1093/jjco/hyp151
M3 - Article
C2 - 19933689
AN - SCOPUS:77950344002
VL - 40
SP - 234
EP - 240
JO - Japanese Journal of Clinical Oncology
JF - Japanese Journal of Clinical Oncology
SN - 0368-2811
IS - 3
M1 - hyp151
ER -