Increased risk of pneumonia in patients receiving gonadotropin-releasing hormone agonists for prostate cancer

Shiu Dong Chung, Shih Ping Liu, Herng Ching Lin, Li Hsuan Wang

研究成果: 雜誌貢獻文章

9 引文 斯高帕斯(Scopus)

摘要

Background: This study aimed to investigate the relationship between the use of gonadotropin-releasing hormone (GnRH) agonists and subsequent risk of pneumonia in patients with prostate cancer (PC) using a population-based dataset. Methods: We obtained the data from Taiwan's Longitudinal Health Insurance Database 2000. We included 2064 PC in this study. Of the sampled PC patients, 1207 received treatment with GnRH agonists. We individually traced each PC patient for a 1-year period to identify those who were hospitalized with pneumonia. We performed a Cox proportional hazard regression to explore the association between the use of GnRH agonists and the risk of pneumonia during the 1-year follow-up period. Results: Incidence rates of pneumonia during the 1-year follow-up period were 4.35 (95% confidence interval (CI): 1.89-9.64) per 100 person-years and 2.14 (95% CI: 1.31-3.32) per 100 person-years for PC patients who did and those who did not receive treatment with GnRH agonists, respectively. The log-rank test suggested that there was a significant difference in the 1-year pneumonia-free survival rate between PC patients who did and those who did not receive treatment with GnRH agonists (p
原文英語
文章編號e101254
期刊PLoS One
9
發行號6
DOIs
出版狀態已發佈 - 六月 27 2014

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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