Increased risk of non-multiple sclerosis demyelinating syndromes in patients with preexisting septicaemia: A nationwide retrospective cohort study

Chung Hsing Chou, Jiunn Tay Lee, Chia Kuang Tsai, Li Ming Lien, Jiu Haw Yin, Chun Chieh Lin, I. Ju Tsai, Yueh Feng Sung, Fu Chi Yang, Chia Lin Tsai, I. Kuan Wang, Chun Hung Tseng, Chung Y. Hsu

研究成果: 雜誌貢獻文章

摘要

Background Growing evidence shows links between septicaemia and non-multiple sclerosis demyelinating syndromes (NMSDS); nevertheless, epidemiological data are still very limited. This study aimed to explore the relationship between septicaemia and NMSDS in a general population. Methods The study included 482 781 individuals diagnosed with septicaemia and 1 892 825 age/sex-matched non-septicaemia patients for the comparison. Data were drawn from a population-based nationwide National Health Insurance Research Database Taiwan, from 1 January 2002 to 31 December 2011. The two cohorts of patients with and without septicaemia were followed up for the occurrence of NMSDS. The Cox-proportional hazard regression model was performed to estimate adjusted HR after multivariate adjustment. Results Individuals with septicaemia had a 4.17-fold (95% CI 3.21 to 5.4, p < 0.001) higher risk to develop NMSDS compared with those without septicaemia. Patients aged <65 years had a greater NMSDS risk (<45 years: HR = 6.41, 95% CI 3.65 to 11.3, p < 0.001; 45-64 years: HR = 6.66, 95% CI 3.98 to 11.2, p < 0.001). Furthermore, females with septicaemia and individuals with higher severity of septicaemia were associated with increased risks of developing NMSDS. Conclusions Our results indicated that patients with septicaemia were likely to develop NMSDS. A possible contributing role of septicaemia in increasing the hazard of NMSDS is proposed, based on the outcome that individuals with higher severity of septicaemia carried elevated threat of encountering NMSDS.
原文英語
頁(從 - 到)307-313
頁數7
期刊Postgraduate Medical Journal
95
發行號1124
DOIs
出版狀態已發佈 - 六月 1 2019

ASJC Scopus subject areas

  • Medicine(all)

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    Chou, C. H., Lee, J. T., Tsai, C. K., Lien, L. M., Yin, J. H., Lin, C. C., Tsai, I. J., Sung, Y. F., Yang, F. C., Tsai, C. L., Wang, I. K., Tseng, C. H., & Hsu, C. Y. (2019). Increased risk of non-multiple sclerosis demyelinating syndromes in patients with preexisting septicaemia: A nationwide retrospective cohort study. Postgraduate Medical Journal, 95(1124), 307-313. https://doi.org/10.1136/postgradmedj-2019-136667