Increased risk of non-multiple sclerosis demyelinating syndromes in patients with preexisting septicaemia: A nationwide retrospective cohort study

Chung Hsing Chou, Jiunn Tay Lee, Chia Kuang Tsai, Li Ming Lien, Jiu Haw Yin, Chun Chieh Lin, I. Ju Tsai, Yueh Feng Sung, Fu Chi Yang, Chia Lin Tsai, I. Kuan Wang, Chun Hung Tseng, Chung Y. Hsu

研究成果: 雜誌貢獻文章

摘要

Background Growing evidence shows links between septicaemia and non-multiple sclerosis demyelinating syndromes (NMSDS); nevertheless, epidemiological data are still very limited. This study aimed to explore the relationship between septicaemia and NMSDS in a general population. Methods The study included 482 781 individuals diagnosed with septicaemia and 1 892 825 age/sex-matched non-septicaemia patients for the comparison. Data were drawn from a population-based nationwide National Health Insurance Research Database Taiwan, from 1 January 2002 to 31 December 2011. The two cohorts of patients with and without septicaemia were followed up for the occurrence of NMSDS. The Cox-proportional hazard regression model was performed to estimate adjusted HR after multivariate adjustment. Results Individuals with septicaemia had a 4.17-fold (95% CI 3.21 to 5.4, p < 0.001) higher risk to develop NMSDS compared with those without septicaemia. Patients aged <65 years had a greater NMSDS risk (<45 years: HR = 6.41, 95% CI 3.65 to 11.3, p < 0.001; 45-64 years: HR = 6.66, 95% CI 3.98 to 11.2, p < 0.001). Furthermore, females with septicaemia and individuals with higher severity of septicaemia were associated with increased risks of developing NMSDS. Conclusions Our results indicated that patients with septicaemia were likely to develop NMSDS. A possible contributing role of septicaemia in increasing the hazard of NMSDS is proposed, based on the outcome that individuals with higher severity of septicaemia carried elevated threat of encountering NMSDS.
原文英語
頁(從 - 到)307-313
頁數7
期刊Postgraduate Medical Journal
95
發行號1124
DOIs
出版狀態已發佈 - 六月 1 2019

指紋

Sclerosis
Sepsis
Cohort Studies
Retrospective Studies
National Health Programs
Taiwan
Proportional Hazards Models
Population
Databases

ASJC Scopus subject areas

  • Medicine(all)

引用此文

Increased risk of non-multiple sclerosis demyelinating syndromes in patients with preexisting septicaemia : A nationwide retrospective cohort study. / Chou, Chung Hsing; Lee, Jiunn Tay; Tsai, Chia Kuang; Lien, Li Ming; Yin, Jiu Haw; Lin, Chun Chieh; Tsai, I. Ju; Sung, Yueh Feng; Yang, Fu Chi; Tsai, Chia Lin; Wang, I. Kuan; Tseng, Chun Hung; Hsu, Chung Y.

於: Postgraduate Medical Journal, 卷 95, 編號 1124, 01.06.2019, p. 307-313.

研究成果: 雜誌貢獻文章

Chou, CH, Lee, JT, Tsai, CK, Lien, LM, Yin, JH, Lin, CC, Tsai, IJ, Sung, YF, Yang, FC, Tsai, CL, Wang, IK, Tseng, CH & Hsu, CY 2019, 'Increased risk of non-multiple sclerosis demyelinating syndromes in patients with preexisting septicaemia: A nationwide retrospective cohort study', Postgraduate Medical Journal, 卷 95, 編號 1124, 頁 307-313. https://doi.org/10.1136/postgradmedj-2019-136667
Chou, Chung Hsing ; Lee, Jiunn Tay ; Tsai, Chia Kuang ; Lien, Li Ming ; Yin, Jiu Haw ; Lin, Chun Chieh ; Tsai, I. Ju ; Sung, Yueh Feng ; Yang, Fu Chi ; Tsai, Chia Lin ; Wang, I. Kuan ; Tseng, Chun Hung ; Hsu, Chung Y. / Increased risk of non-multiple sclerosis demyelinating syndromes in patients with preexisting septicaemia : A nationwide retrospective cohort study. 於: Postgraduate Medical Journal. 2019 ; 卷 95, 編號 1124. 頁 307-313.
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title = "Increased risk of non-multiple sclerosis demyelinating syndromes in patients with preexisting septicaemia: A nationwide retrospective cohort study",
abstract = "Background Growing evidence shows links between septicaemia and non-multiple sclerosis demyelinating syndromes (NMSDS); nevertheless, epidemiological data are still very limited. This study aimed to explore the relationship between septicaemia and NMSDS in a general population. Methods The study included 482 781 individuals diagnosed with septicaemia and 1 892 825 age/sex-matched non-septicaemia patients for the comparison. Data were drawn from a population-based nationwide National Health Insurance Research Database Taiwan, from 1 January 2002 to 31 December 2011. The two cohorts of patients with and without septicaemia were followed up for the occurrence of NMSDS. The Cox-proportional hazard regression model was performed to estimate adjusted HR after multivariate adjustment. Results Individuals with septicaemia had a 4.17-fold (95{\%} CI 3.21 to 5.4, p < 0.001) higher risk to develop NMSDS compared with those without septicaemia. Patients aged <65 years had a greater NMSDS risk (<45 years: HR = 6.41, 95{\%} CI 3.65 to 11.3, p < 0.001; 45-64 years: HR = 6.66, 95{\%} CI 3.98 to 11.2, p < 0.001). Furthermore, females with septicaemia and individuals with higher severity of septicaemia were associated with increased risks of developing NMSDS. Conclusions Our results indicated that patients with septicaemia were likely to develop NMSDS. A possible contributing role of septicaemia in increasing the hazard of NMSDS is proposed, based on the outcome that individuals with higher severity of septicaemia carried elevated threat of encountering NMSDS.",
keywords = "acute disseminated encephalomyelitis, demyelination, septicaemia, transverse myelitis",
author = "Chou, {Chung Hsing} and Lee, {Jiunn Tay} and Tsai, {Chia Kuang} and Lien, {Li Ming} and Yin, {Jiu Haw} and Lin, {Chun Chieh} and Tsai, {I. Ju} and Sung, {Yueh Feng} and Yang, {Fu Chi} and Tsai, {Chia Lin} and Wang, {I. Kuan} and Tseng, {Chun Hung} and Hsu, {Chung Y.}",
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TY - JOUR

T1 - Increased risk of non-multiple sclerosis demyelinating syndromes in patients with preexisting septicaemia

T2 - A nationwide retrospective cohort study

AU - Chou, Chung Hsing

AU - Lee, Jiunn Tay

AU - Tsai, Chia Kuang

AU - Lien, Li Ming

AU - Yin, Jiu Haw

AU - Lin, Chun Chieh

AU - Tsai, I. Ju

AU - Sung, Yueh Feng

AU - Yang, Fu Chi

AU - Tsai, Chia Lin

AU - Wang, I. Kuan

AU - Tseng, Chun Hung

AU - Hsu, Chung Y.

PY - 2019/6/1

Y1 - 2019/6/1

N2 - Background Growing evidence shows links between septicaemia and non-multiple sclerosis demyelinating syndromes (NMSDS); nevertheless, epidemiological data are still very limited. This study aimed to explore the relationship between septicaemia and NMSDS in a general population. Methods The study included 482 781 individuals diagnosed with septicaemia and 1 892 825 age/sex-matched non-septicaemia patients for the comparison. Data were drawn from a population-based nationwide National Health Insurance Research Database Taiwan, from 1 January 2002 to 31 December 2011. The two cohorts of patients with and without septicaemia were followed up for the occurrence of NMSDS. The Cox-proportional hazard regression model was performed to estimate adjusted HR after multivariate adjustment. Results Individuals with septicaemia had a 4.17-fold (95% CI 3.21 to 5.4, p < 0.001) higher risk to develop NMSDS compared with those without septicaemia. Patients aged <65 years had a greater NMSDS risk (<45 years: HR = 6.41, 95% CI 3.65 to 11.3, p < 0.001; 45-64 years: HR = 6.66, 95% CI 3.98 to 11.2, p < 0.001). Furthermore, females with septicaemia and individuals with higher severity of septicaemia were associated with increased risks of developing NMSDS. Conclusions Our results indicated that patients with septicaemia were likely to develop NMSDS. A possible contributing role of septicaemia in increasing the hazard of NMSDS is proposed, based on the outcome that individuals with higher severity of septicaemia carried elevated threat of encountering NMSDS.

AB - Background Growing evidence shows links between septicaemia and non-multiple sclerosis demyelinating syndromes (NMSDS); nevertheless, epidemiological data are still very limited. This study aimed to explore the relationship between septicaemia and NMSDS in a general population. Methods The study included 482 781 individuals diagnosed with septicaemia and 1 892 825 age/sex-matched non-septicaemia patients for the comparison. Data were drawn from a population-based nationwide National Health Insurance Research Database Taiwan, from 1 January 2002 to 31 December 2011. The two cohorts of patients with and without septicaemia were followed up for the occurrence of NMSDS. The Cox-proportional hazard regression model was performed to estimate adjusted HR after multivariate adjustment. Results Individuals with septicaemia had a 4.17-fold (95% CI 3.21 to 5.4, p < 0.001) higher risk to develop NMSDS compared with those without septicaemia. Patients aged <65 years had a greater NMSDS risk (<45 years: HR = 6.41, 95% CI 3.65 to 11.3, p < 0.001; 45-64 years: HR = 6.66, 95% CI 3.98 to 11.2, p < 0.001). Furthermore, females with septicaemia and individuals with higher severity of septicaemia were associated with increased risks of developing NMSDS. Conclusions Our results indicated that patients with septicaemia were likely to develop NMSDS. A possible contributing role of septicaemia in increasing the hazard of NMSDS is proposed, based on the outcome that individuals with higher severity of septicaemia carried elevated threat of encountering NMSDS.

KW - acute disseminated encephalomyelitis

KW - demyelination

KW - septicaemia

KW - transverse myelitis

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U2 - 10.1136/postgradmedj-2019-136667

DO - 10.1136/postgradmedj-2019-136667

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