Increased risk of major depressive disorder among probands with psoriasis and unaffected siblings: a nationwide population-based study

Y. X. Dai, C. C. Chen, Y. H. Tai, Y. T. Chang, T. J. Chen, M. H. Chen

研究成果: 雜誌貢獻文章同行評審

9 引文 斯高帕斯(Scopus)

摘要

Background: Previous studies have shown that patients with psoriasis have a higher risk of depression. However, the risk of major depressive disorder (MDD) among unaffected siblings of psoriasis probands remains unknown. This study aimed to investigate the risk of MDD among probands with psoriasis and unaffected siblings. Methods: We selected subjects from the National Health Insurance Research Database (NHIRD) in Taiwan. Subjects were followed up from 01 January 1996 until a diagnosis of MDD, death or 31 December 2011. The Breslow–Cox model was used to calculate the adjusted relative risk (aRR). Results: This study included 1094 probands with psoriasis, 1202 unaffected siblings and 4808 matched controls. Overall, 11.9% of the psoriasis probands (n = 130) and 2.5% of the unaffected siblings (n = 30) developed MDD, as compared with 1.1% of the controls (n = 52). Compared with controls, probands with psoriasis and unaffected siblings had aRRs of 10.60 [95% confidence interval (CI): 7.73–14.52] and 2.17 (95% CI: 1.44–3.28), respectively, for MDD. Conclusions: Probands with psoriasis and unaffected siblings have an increased risk of subsequently developing MDD. Further studies are needed to investigate the shared familial mechanisms underlying psoriasis and MDD.

原文英語
頁(從 - 到)1510-1515
頁數6
期刊Journal of the European Academy of Dermatology and Venereology
34
發行號7
DOIs
出版狀態接受/付印 - 一月 1 2020

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases

指紋 深入研究「Increased risk of major depressive disorder among probands with psoriasis and unaffected siblings: a nationwide population-based study」主題。共同形成了獨特的指紋。

引用此