Increased risk of low birthweight, infants small for gestational age, and preterm delivery for women with peptic ulcer

Yi-Hua Chen, Herng Ching Lin, Horng Yuan Lou

研究成果: 雜誌貢獻文章

4 引文 斯高帕斯(Scopus)


Objective: The objective of the study was to determine whether maternal peptic ulcer disease (PUD) is associated with increased risk of adverse pregnancy outcomes, using a nationwide population-based dataset. Study Design: We identified a total of 2120 women who gave birth from 2001 to 2003 with a diagnosis of PUD during pregnancy. Then 10,600 unaffected pregnant women were matched with cases in age and year of delivery. Multivariate logistic regression analyses were performed for estimation. Results: We found that PUD was independently associated with a 1.18-fold risk of low birthweight (95% confidence interval [CI], 1.01-1.30), a 1.20-fold risk of preterm delivery (95% CI, 1.02-1.41), and a 1.25-fold (95% CI, 1.11-1.41) higher risk of babies small for gestational age, compared with unaffected mothers, after adjusting for potential confounders. In further examining women with treated PUD, improved effects of PUD medication on the risks of adverse neonate outcomes were not identified. Conclusion: We document increased risk of adverse birth outcomes for women with PUD during pregnancy.
頁(從 - 到)164.e1-164.e8
期刊American Journal of Obstetrics and Gynecology
出版狀態已發佈 - 二月 2010



  • low birthweight
  • peptic ulcer
  • pregnancy outcome
  • preterm birth
  • small for gestational age

ASJC Scopus subject areas

  • Obstetrics and Gynaecology