Increased risk of ischemic stroke in patients with systemic lupus erythematosus:A nationwide population-based study

Chun Chih Chiu, Chin Chou Huang, Wan Leong Chan, Chia Min Chung, Po Hsun Huang, Shing Jong Lin, Jaw Wen Chen, Hsin Bang Leu

研究成果: 雜誌貢獻文章同行評審

37 引文 斯高帕斯(Scopus)

摘要

Background Systemic lupus erythematosus (SLE) has been reported to be associated with an increased risk of cardiovascular disease. However, most studies have been criticized for either a small sample size or the lack of a prospective control. Our study investigated the relationship of SLE and the subsequent development of ischemic stroke using a nationwide, population-based database in an Asian population. Methods From 2000 to 2007, we identified a study cohort consisting of a total of 11,637 newly diagnosed SLE patients using the National Health Insurance Research Database in Taiwan. A control cohort of 58,185 subjects without SLE, matched for age, gender, and comorbidities were selected for comparison to observe the occurrence of ischemic stroke in these two groups. Results During a follow-up period of up to 7 years, ischemic stroke developed in 258 (2.22%) of the patients with SLE and in 873 (1.5%) of patients in the comparison cohort. Kaplan-Meier analysis also revealed a tendency of SLE patients toward ischemic stroke development (log rank test, p = 0.001). After Cox model adjustment for patients' demographic characteristics and selected comorbidities, patients with SLE were found to have a 1.67-fold (95% CI, 1.45 to 1.91) higher risk of developing ischemic stroke. Conclusion Patients with SLE have an increased risk of stroke.

原文英語
頁(從 - 到)17-21
頁數5
期刊Internal Medicine
51
發行號1
DOIs
出版狀態已發佈 - 一月 4 2012
對外發佈

ASJC Scopus subject areas

  • 內科學

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